The Role of Vascular Lesions in Diabetes Across a Spectrum of Clinical Kidney Disease.
albuminuria
chronic kidney disease
diabetes
diabetic nephropathy
histology
normoalbuminuria
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
14
05
2021
accepted:
04
06
2021
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
14
9
2021
Statut:
epublish
Résumé
The clinical-histologic correlation in diabetic nephropathy is not completely known. We analyzed nephrectomy specimens from 90 patients with diabetes and diverse degrees of proteinuria and glomerular filtration rate (GFR). Thirty-six (40%) subjects had normoalbuminuria, 33 (37%) microalbuminuria, and 21 (23%) non-nephrotic proteinuria. Mean estimated GFR (eGFR) was 65±23 (40% <60 ml/min per 1.73 m Weak correspondence between analytical parameters and kidney histology was found. Thus, disease may progress undetected from the early clinical stages of the disease. Finally, vascular damage was a very common finding, which highlights the role of ischemic intrarenal disease in diabetes.
Identifiants
pubmed: 34514200
doi: 10.1016/j.ekir.2021.06.001
pii: S2468-0249(21)01227-4
pmc: PMC8419124
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2392-2403Informations de copyright
© 2021 Published by Elsevier, Inc., on behalf of the International Society of Nephrology.
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