Lost in translation. The quest for definitions of treatment-resistant depression with a focus on inflammation-related gene expression.
Biomarkers
Genome-wide gene expression
Major depressive disorder (MDD)
RNA-seq
Transcriptomics
Treatment-resistant depression (TRD)
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
14
9
2021
Statut:
epublish
Résumé
Approximately one third of individuals with major depressive disorder (MDD) do not respond to antidepressant treatments; but what does treatment-resistant depression (TRD) mean? With this article, I aim to provide an overview of the clinical and operational criteria currently used to define TRD, highlighting core gaps in knowledge and open questions to be addressed in order to drive future research in the field. Importantly, a better definition of TRD must include a better characterization of the biological and molecular correlates of non-response. Among these potential biomarkers, compelling evidence reveals a potential role of inflammation-related gene expression signatures. A more accurate clinical and etiopathological characterization of TRD subjects may help to identify biologically based MDD clinical phenotypes to be targeted in future research and finally achieve better outcomes.
Identifiants
pubmed: 34514443
doi: 10.1016/j.bbih.2021.100331
pmc: PMC7611643
mid: EMS133944
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100331Subventions
Organisme : Wellcome Trust
ID : 104025
Pays : United Kingdom
Déclaration de conflit d'intérêts
Conflict of interests Dr. Sforzini reports grant from European Commission (IMI2 853966).
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