[11C]CS1P1 PET imaging
[3H]CS1P1 autoradiography
central nervous system
positron emission tomography
radiopharmaceutical
sphingosine-1-phosphate receptor 1
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
06 10 2021
06 10 2021
Historique:
pubmed:
14
9
2021
medline:
31
10
2021
entrez:
13
9
2021
Statut:
ppublish
Résumé
Sphingosine-1-phosphate receptor 1 (S1PR1) is ubiquitously expressed among all tissues and plays key roles in many physiological and cellular processes. In the central nervous system (CNS), S1PR1 is expressed in different types of cells including neurons, astrocytes, and oligodendrocyte precursor cells. S1PR1 has been recognized as a novel therapeutic target in multiple sclerosis and other diseases. We previously reported a promising S1PR1-specific radioligand, [
Identifiants
pubmed: 34516079
doi: 10.1021/acschemneuro.1c00492
pmc: PMC8605766
mid: NIHMS1751173
doi:
Substances chimiques
Receptors, Lysosphingolipid
0
S1PR1 protein, rat
0
Sphingosine-1-Phosphate Receptors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3733-3744Subventions
Organisme : NINDS NIH HHS
ID : R01 NS103988
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103957
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075527
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB025815
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107281
Pays : United States
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