Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of


Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
Sep 2021
Historique:
entrez: 13 9 2021
pubmed: 14 9 2021
medline: 3 11 2021
Statut: ppublish

Résumé

The clinical efficacy of epidermal growth factor receptor (EGFR)–targeted therapy in

Identifiants

pubmed: 34516823
doi: 10.1126/scitranslmed.abb3738
pmc: PMC8627689
mid: NIHMS1758040
doi:

Substances chimiques

Protein Kinase Inhibitors 0
EGFR protein, human EC 2.7.10.1
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabb3738

Subventions

Organisme : NCI NIH HHS
ID : F31 CA192623
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA222823
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA220497
Pays : United States
Organisme : NLM NIH HHS
ID : T15 LM007092
Pays : United States

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Auteurs

Pınar Özden Eser (PÖ)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
Harvard Medical School, Boston, MA 02115, USA.

Raymond M Paranal (RM)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Jieun Son (J)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Elena Ivanova (E)

Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Yanan Kuang (Y)

Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Heidi M Haikala (HM)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Ciric To (C)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Jeffrey J Okoro (JJ)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Kshiti H Dholakia (KH)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Jihyun Choi (J)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Yoonji Eum (Y)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Atsuko Ogino (A)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Pavlos Missios (P)

Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.

Dalia Ercan (D)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Man Xu (M)

Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Michael J Poitras (MJ)

Experimental Therapeutics Core, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Stephen Wang (S)

Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Kenneth Ngo (K)

Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Michael Dills (M)

Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Masahiko Yanagita (M)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Timothy Lopez (T)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Mika Lin (M)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Jeanelle Tsai (J)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Nicolas Floch (N)

Oncology R&D, Bioscience, AstraZeneca, CRUK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK.

Emily S Chambers (ES)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Jennifer Heng (J)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Rana Anjum (R)

Bioscience, Oncology R&D, AstraZeneca, 25 Gatehouse Park, Waltham, MA 02451, USA.

Alison D Santucci (AD)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Kesi Michael (K)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Alwin G Schuller (AG)

Bioscience, Oncology R&D, AstraZeneca, 25 Gatehouse Park, Waltham, MA 02451, USA.

Darren Cross (D)

Global Medical Affairs, Oncology Business Unit, AstraZeneca, 136 Hills Road, Cambridge CB2 8PA, UK.

Paul D Smith (PD)

Oncology R&D, Bioscience, AstraZeneca, CRUK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK.

Geoffrey R Oxnard (GR)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

David A Barbie (DA)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Lynette M Sholl (LM)

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Magda Bahcall (M)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Sangeetha Palakurthi (S)

Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Prafulla C Gokhale (PC)

Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Experimental Therapeutics Core, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Cloud P Paweletz (CP)

Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

George Q Daley (GQ)

Harvard Medical School, Boston, MA 02115, USA.
Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.
Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

Pasi A Jänne (PA)

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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Classifications MeSH