SERS liquid biopsy: An emerging tool for medical diagnosis.
Carotenoids
Proteins
Purine metabolites
SERS liquid biopsy
Surface-enhanced Raman scattering
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
24
05
2021
revised:
09
08
2021
accepted:
20
08
2021
pubmed:
14
9
2021
medline:
17
11
2021
entrez:
13
9
2021
Statut:
ppublish
Résumé
Surface-enhanced Raman scattering (SERS) is emerging as a novel strategy for biofluid analysis. In this review, we delineate four experimental SERS protocols that are frequently used for the profiling of biofluids: 1) liquid SERS for the detection of purine metabolites; 2) iodide-modified liquid SERS for the detection of proteins; 3) dried SERS for the detection of both purine metabolites and proteins; 4) resonant Raman for the detection of carotenoids. To explain the selectivity of each experimental SERS protocol, we introduce a heuristic model for the chemisorption of analytes mediated by adsorbed ions (adions) onto the SERS substrate. Next, we show that the promising results of SERS liquid biopsy stem from the fact that the concentration levels of purine metabolites, proteins and carotenoids are informative of the cellular turnover rate, inflammation, and oxidative stress, respectively. These processes are perturbed in virtually every disease, from cancer to autoimmune maladies. Finally, we review recent SERS liquid biopsy studies and discuss future steps that are required for translating SERS in the clinical setting.
Identifiants
pubmed: 34517219
pii: S0927-7765(21)00508-7
doi: 10.1016/j.colsurfb.2021.112064
pii:
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
112064Informations de copyright
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