Dopamine release during psychological stress in euthymic bipolar I disorder: a Positron Emission Tomography study with [

Bipolar Disorder / diagnostic imaging Dopamine Humans Positron-Emission Tomography Raclopride Stress, Psychological / diagnostic imaging
Bipolar disorder Dopamine Functional neuroimaging Neurobiology Positron emission tomography

Journal

Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073

Informations de publication

Date de publication:
01 12 2021
Historique:
received: 06 07 2021
revised: 08 08 2021
accepted: 18 08 2021
pubmed: 14 9 2021
medline: 3 11 2021
entrez: 13 9 2021
Statut: ppublish

Résumé

Neurochemical mechanisms underlying stress induced relapse of mood episodes in Bipolar I Disorder (BD) remain unknown. This study investigated whether euthymic BD patients have a greater dopamine release in ventral striatum, caudate and putamen in response to psychological stress using Positron Emission Tomography (PET) scanning with the radiotracer [ Euthymic patients with BD (n = 10) and 10 matched healthy controls underwent two [ There was a significant effect of stress in reducing the [ Small sample size and recruitment of euthymic patients who may be less vulnerable to stress may limit the generalizability of findings. Our findings showed that psychological stress led to dopamine release in the basal ganglia for all participants but the magnitude of dopamine release during a stress task was not different between euthymic BD patients and healthy controls.

Sections du résumé

BACKGROUND
Neurochemical mechanisms underlying stress induced relapse of mood episodes in Bipolar I Disorder (BD) remain unknown. This study investigated whether euthymic BD patients have a greater dopamine release in ventral striatum, caudate and putamen in response to psychological stress using Positron Emission Tomography (PET) scanning with the radiotracer [
METHODS
Euthymic patients with BD (n = 10) and 10 matched healthy controls underwent two [
RESULTS
There was a significant effect of stress in reducing the [
LIMITATIONS
Small sample size and recruitment of euthymic patients who may be less vulnerable to stress may limit the generalizability of findings.
CONCLUSIONS
Our findings showed that psychological stress led to dopamine release in the basal ganglia for all participants but the magnitude of dopamine release during a stress task was not different between euthymic BD patients and healthy controls.

Identifiants

DOI: 10.1016/j.jad.2021.08.022 PMID: 34517246
pubmed: 34517246
pii: S0165-0327(21)00820-X
doi: 10.1016/j.jad.2021.08.022
pii:
doi:

Substances chimiques

Raclopride 430K3SOZ7G
Dopamine VTD58H1Z2X

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

724-732

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Gayatri Saraf (G)

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

Jairo Vinícius Pinto (JV)

Department of Psychiatry, University of British Columbia, Vancouver, Canada; Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Ariana Cahn (A)

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

Adam George White (AG)

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

Elham Shahinfard (E)

Djavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.

Nasim Vafai (N)

Djavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.

Vesna Sossi (V)

Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada.

Lakshmi N Yatham (LN)

Department of Psychiatry, University of British Columbia, Vancouver, Canada. Electronic address: l.yatham@ubc.ca.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Troubles bipolaires et apparentés › Trouble bipolaire › Dopamine release during psychological stress...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Dopamine release during psychological stress...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dopamine release during psychological stress...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Dopamine release during psychological stress...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Chloro-benzoates › Raclopride › Dopamine release during psychological stress...
questionsmedicales.fr › Phénomènes psychologiques › Stress psychologique › Dopamine release during psychological stress...