Studying Stroke Thrombus Composition After Thrombectomy: What Can We Learn?
fibrin
ischemic stroke
leukocytes
thrombectomy
von Willebrand Factor
Journal
Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
pubmed:
15
9
2021
medline:
8
1
2022
entrez:
14
9
2021
Statut:
ppublish
Résumé
The composition of ischemic stroke thrombi has gained an increasing amount of interest in recent years. The implementation of endovascular procedures in standard stroke care has granted researchers the unique opportunity to examine patient thrombus material. Increasing evidence indicates that stroke thrombi are complex and heterogenous, consisting of various biochemical (eg, fibrin, von Willebrand Factor, and neutrophil extracellular traps) and cellular (eg, red blood cells, platelets, leukocytes, and bacteria) components. This complex composition may explain therapeutic limitations and also offer novel insights in several aspects of stroke management. Better understanding of thrombus characteristics could, therefore, potentially lead to improvements in the management of patients with stroke. In this review, we provide a comprehensive overview of the lessons learned by examining stroke thrombus composition after endovascular thrombectomy and its potential relevance for thrombectomy success rates, thrombolysis, clinical outcomes, stroke etiology, and radiological imaging.
Identifiants
pubmed: 34517770
doi: 10.1161/STROKEAHA.121.034289
pmc: PMC8545837
mid: NIHMS1735522
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3718-3727Subventions
Organisme : NINDS NIH HHS
ID : R01 NS105853
Pays : United States
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