SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca
Animals
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Calcium
/ metabolism
Cell Line, Tumor
DNA Helicases
/ genetics
Gene Expression Profiling
/ methods
Gene Expression Regulation, Neoplastic
HEK293 Cells
Humans
Inositol 1,4,5-Trisphosphate Receptors
/ metabolism
Ion Transport
/ genetics
Male
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Mitochondria
/ metabolism
Mutation
Neoplasms
/ drug therapy
Nuclear Proteins
/ genetics
Transcription Factors
/ genetics
Xenograft Model Antitumor Assays
/ methods
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 09 2021
13 09 2021
Historique:
received:
19
08
2020
accepted:
27
07
2021
entrez:
14
9
2021
pubmed:
15
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2 characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of SWI/SNF chromatin remodeling complexes in both cancers is associated with chemotherapy resistance and poor prognosis. Here, we discover that SMARCA4/2 loss inhibits chemotherapy-induced apoptosis through disrupting intracellular organelle calcium ion (Ca
Identifiants
pubmed: 34518526
doi: 10.1038/s41467-021-25260-9
pii: 10.1038/s41467-021-25260-9
pmc: PMC8438089
doi:
Substances chimiques
Antineoplastic Agents
0
ITPR3 protein, human
0
Inositol 1,4,5-Trisphosphate Receptors
0
Nuclear Proteins
0
SMARCA2 protein, human
0
Transcription Factors
0
SMARCA4 protein, human
EC 3.6.1.-
DNA Helicases
EC 3.6.4.-
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5404Subventions
Organisme : CIHR
ID : MOP-130540
Pays : Canada
Organisme : CIHR
ID : PJT-156233
Pays : Canada
Organisme : CIHR
ID : PJT-438303
Pays : Canada
Organisme : CIHR
ID : FDN-148390
Pays : Canada
Organisme : Medical Research Council
ID : MC_UU_00015/7
Pays : United Kingdom
Organisme : CIHR
ID : MFE-171249
Pays : Canada
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
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