Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
13 Sep 2021
13 Sep 2021
Historique:
received:
05
10
2020
accepted:
29
07
2021
entrez:
14
9
2021
pubmed:
15
9
2021
medline:
15
9
2021
Statut:
epublish
Résumé
Knowledge of the Plasmodium falciparum antigens that comprise the human liver stage immunoproteome is important for pre-erythrocytic vaccine development, but, compared with the erythrocytic stage immunoproteome, more challenging to classify. Previous studies of P. falciparum antibody responses report IgG and rarely IgA responses. We assessed IgG and IgA antibody responses in adult sera collected during two controlled human malaria infection (CHMI) studies in malaria-naïve volunteers and in 1- to 6-year-old malaria-exposed Malian children on a 251 P. falciparum antigen protein microarray. IgG profiles in the two CHMI groups were equivalent and differed from Malian children. IgA profiles were robust in the CHMI groups and a subset of Malian children. We describe immunoproteome differences in naïve vs. exposed individuals and report pre-erythrocytic proteins recognized by the immune system. IgA responses detected in this study expand the list of pre-erythrocytic antigens for further characterization as potential vaccine candidates.
Identifiants
pubmed: 34518543
doi: 10.1038/s41541-021-00363-y
pii: 10.1038/s41541-021-00363-y
pmc: PMC8438027
doi:
Types de publication
Journal Article
Langues
eng
Pagination
115Subventions
Organisme : NIAID NIH HHS
ID : R44 AI058375
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI110820
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI067954
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI095916
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141900
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : K23AI125720
Organisme : NIAID NIH HHS
ID : U01 AI110852
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW001589
Pays : United States
Organisme : NIAID NIH HHS
ID : N01AI25461
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272200800057C
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : K01HL140285-01A1
Organisme : NIAID NIH HHS
ID : U01 AI089342
Pays : United States
Organisme : NIAID NIH HHS
ID : R44 AI055229
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL140285
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : U19AI089686
Organisme : NIAID NIH HHS
ID : U19 AI065683
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201500002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130750
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI089686
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : R01AI095916
Organisme : NIAID NIH HHS
ID : K23 AI125720
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003098
Pays : United States
Informations de copyright
© 2021. The Author(s).
Références
Int J Parasitol. 2011 Jan;41(1):3-20
pubmed: 20816843
N Engl J Med. 2011 Sep 15;365(11):1004-13
pubmed: 21916638
Science. 2003 Sep 12;301(5639):1503-8
pubmed: 12893887
Immunology. 2018 Apr;153(4):423-434
pubmed: 29211303
J Leukoc Biol. 2017 Nov;102(5):1261-1269
pubmed: 28807929
PLoS One. 2014 Sep 25;9(9):e107903
pubmed: 25254500
Genome Med. 2020 Jan 8;12(1):6
pubmed: 31915075
PLoS One. 2010 Oct 21;5(10):e13490
pubmed: 21042404
J Exp Med. 2004 Nov 1;200(9):1197-203
pubmed: 15520249
J Immunol. 2017 Jul 1;199(1):107-118
pubmed: 28576979
J Infect Dis. 2019 Nov 6;220(12):1962-1966
pubmed: 31419294
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1772-81
pubmed: 22619330
PLoS One. 2013 Jul 16;8(7):e68969
pubmed: 23874828
Parasite Immunol. 2009 Sep;31(9):547-59
pubmed: 19691558
Proteomics. 2018 Jan;18(2):
pubmed: 29266845
Sci Rep. 2020 Mar 3;10(1):3952
pubmed: 32127565
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):547-52
pubmed: 15647345
Cell Microbiol. 2012 Mar;14(3):343-55
pubmed: 22188297
Cell Rep. 2016 Dec 20;17(12):3193-3205
pubmed: 28009289
Infect Immun. 2003 Nov;71(11):6620-3
pubmed: 14573685
Science. 1996 Jun 7;272(5267):1502-4
pubmed: 8633247
Sci Rep. 2018 Apr 19;8(1):6281
pubmed: 29674705
Science. 2000 Jun 23;288(5474):2222-6
pubmed: 10864873
J Immunol. 2017 Nov 15;199(10):3691-3699
pubmed: 29030488
PLoS One. 2018 Jun 8;13(6):e0198371
pubmed: 29883485
Mol Microbiol. 2003 Jul;49(1):179-91
pubmed: 12823820
J Infect Dis. 2003 Feb 15;187(4):667-74
pubmed: 12599084
Mucosal Immunol. 2008 Jan;1(1):11-22
pubmed: 19079156
EBioMedicine. 2020 Apr;54:102733
pubmed: 32315970
Nat Rev Microbiol. 2020 Mar;18(3):177-189
pubmed: 31919479
J Exp Med. 2000 May 1;191(9):1477-86
pubmed: 10790423
Parasitology. 2016 Feb;143(2):139-53
pubmed: 26741253
Clin Microbiol Rev. 2009 Jan;22(1):13-36, Table of Contents
pubmed: 19136431
Curr Top Microbiol Immunol. 2005;295:417-38
pubmed: 16265900
Malar J. 2015 Aug 04;14:294
pubmed: 26238109
Blood Adv. 2018 Dec 11;2(23):3462-3478
pubmed: 30518538
Mucosal Immunol. 2014 May;7(3):511-20
pubmed: 24064668
Am J Trop Med Hyg. 2015 Jun;92(6):1190-1194
pubmed: 25918203
Nat Rev Immunol. 2018 Apr;18(4):266-278
pubmed: 29332936
mSphere. 2019 Feb 20;4(1):
pubmed: 30787114
Immunol Rev. 2020 Jan;293(1):190-215
pubmed: 31840844
Trends Parasitol. 2016 Nov;32(11):887-898
pubmed: 27546781
Sci Rep. 2013 Dec 19;3:3549
pubmed: 24351974
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):305-10
pubmed: 18172196
Malar J. 2008 Sep 24;7:186
pubmed: 18816374
Parasite Immunol. 2006 Jan-Feb;28(1-2):51-60
pubmed: 16438676
Front Immunol. 2018 May 07;9:985
pubmed: 29867962
Nat Rev Microbiol. 2014 Dec;12(12):833-40
pubmed: 25329408
Nat Med. 2016 Jun;22(6):614-23
pubmed: 27158907
Nat Commun. 2019 Jan 30;10(1):488
pubmed: 30700707