Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization.


Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
02 2022
Historique:
received: 15 02 2021
accepted: 01 09 2021
revised: 23 08 2021
pubmed: 15 9 2021
medline: 16 2 2022
entrez: 14 9 2021
Statut: ppublish

Résumé

We show that pro-inflammatory oncostatin M (OSM) is an important regulator of hematopoietic stem cell (HSC) niches in the bone marrow (BM). Treatment of healthy humans and mice with granulocyte colony-stimulating factor (G-CSF) dramatically increases OSM release in blood and BM. Using mice null for the OSM receptor (OSMR) gene, we demonstrate that OSM provides a negative feed-back acting as a brake on HSPC mobilization in response to clinically relevant mobilizing molecules G-CSF and CXCR4 antagonist. Likewise, injection of a recombinant OSM molecular trap made of OSMR complex extracellular domains enhances HSC mobilization in poor mobilizing C57BL/6 and NOD.Cg-Prkdc

Identifiants

pubmed: 34518644
doi: 10.1038/s41375-021-01413-z
pii: 10.1038/s41375-021-01413-z
doi:

Substances chimiques

Oncostatin M 106956-32-5
Granulocyte Colony-Stimulating Factor 143011-72-7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

333-347

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Kavita Bisht (K)

Mater Research Institute-The University of Queensland, Woolloongabba, QLD, 4102, Australia.

Crystal McGirr (C)

Mater Research Institute-The University of Queensland, Woolloongabba, QLD, 4102, Australia.

Seo-Youn Lee (SY)

Goethe University, Institute for Transfusion Medicine and Immunohematology, and German Red Cross Blood Donor Service Baden-Wuerttemberg-Hessen, Frankfurt, Germany.

Hsu-Wen Tseng (HW)

Mater Research Institute-The University of Queensland, Woolloongabba, QLD, 4102, Australia.

Whitney Fleming (W)

Mater Research Institute-The University of Queensland, Woolloongabba, QLD, 4102, Australia.

Kylie A Alexander (KA)

Mater Research Institute-The University of Queensland, Woolloongabba, QLD, 4102, Australia.

Taichi Matsumoto (T)

Mater Research Institute-The University of Queensland, Woolloongabba, QLD, 4102, Australia.
Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.

Valérie Barbier (V)

Mater Research Institute-The University of Queensland, Woolloongabba, QLD, 4102, Australia.

Natalie A Sims (NA)

Saint Vincent Institute, Fitzroy, VIC, 3065, Australia.

Gerhard Müller-Newen (G)

Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Aachen, Germany.

Ingrid G Winkler (IG)

Mater Research Institute-The University of Queensland, Woolloongabba, QLD, 4102, Australia.

Halvard Bonig (H)

Goethe University, Institute for Transfusion Medicine and Immunohematology, and German Red Cross Blood Donor Service Baden-Wuerttemberg-Hessen, Frankfurt, Germany.

Jean-Pierre Lévesque (JP)

Mater Research Institute-The University of Queensland, Woolloongabba, QLD, 4102, Australia. jp.levesque@mater.uq.edu.au.

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