Pruritus in Keloid Scars: Mechanisms and Treatments.
Journal
Acta dermato-venereologica
ISSN: 1651-2057
Titre abrégé: Acta Derm Venereol
Pays: Sweden
ID NLM: 0370310
Informations de publication
Date de publication:
28 Oct 2021
28 Oct 2021
Historique:
pubmed:
15
9
2021
medline:
3
11
2021
entrez:
14
9
2021
Statut:
epublish
Résumé
Keloids are scars that extend beyond the margins of an insulting cutaneous injury. Keloids are often thought to be primarily a cosmetic issue, as they are typically quite raised and pigmented. However, these scars also present with functional symptoms of pruritus and pain that significantly impact quality of life. The symptom of pruritus is frequently overlooked by dermatologists, and treatments are often primarily focused on the gross appearance of the scar. This review describes the prevalence and importance of pruritus in keloids. In addition, the putative mechanisms underlying the development of keloid pruritus, which include neuronal and immunological mechanisms, are discussed. Furthermore, this review describes keloid treatments that have been shown to reduce pruritus, treatments that specifically target the itch, and emerging therapies.
Identifiants
pubmed: 34518894
doi: 10.2340/00015555-3923
pmc: PMC9425615
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
adv00582Références
J Invest Dermatol. 2003 Sep;121(3):570-7
pubmed: 12925217
Aesthetic Plast Surg. 2010 Aug;34(4):424-7
pubmed: 19802513
Clin Immunol. 2015 May;158(1):1-7
pubmed: 25762519
Adv Wound Care (New Rochelle). 2014 Apr 1;3(4):356-365
pubmed: 24757590
Dermatol Surg. 2001 Jan;27(1):23-7
pubmed: 11231236
J Burn Care Res. 2011 Jul-Aug;32(4):e118-25
pubmed: 21747328
Plast Reconstr Surg. 2003 May;111(6):1841-52
pubmed: 12711943
Exp Cell Res. 2018 Jan 15;362(2):472-476
pubmed: 29253537
BMJ Open. 2018 Jul 18;8(7):e022865
pubmed: 30021755
Pain. 2010 May;149(2):316-324
pubmed: 20223589
Clin Exp Dermatol. 2009 Mar;34(2):219-23
pubmed: 19018794
J Clin Aesthet Dermatol. 2013 Jul;6(7):23-6
pubmed: 23882311
Wound Repair Regen. 2010 May-Jun;18(3):319-24
pubmed: 20412553
Ann Allergy Asthma Immunol. 2019 Aug;123(2):158-165
pubmed: 30685562
Br J Dermatol. 2008 Apr;158(4):713-20
pubmed: 18284397
Immunity. 2020 Aug 18;53(2):371-383.e5
pubmed: 32673566
Exp Dermatol. 2021 Jun;30(6):804-810
pubmed: 33428793
Int J Mol Sci. 2017 Mar 10;18(3):
pubmed: 28287424
Plast Reconstr Surg. 2002 Aug;110(2):560-71
pubmed: 12142678
J Allergy Clin Immunol. 1988 Oct;82(4):599-607
pubmed: 2459178
Chin Med J (Engl). 2020 Sep 20;133(18):2236-2238
pubmed: 32769490
Acta Derm Venereol. 2021 Jan 20;101(1):adv00375
pubmed: 33236123
J Am Acad Dermatol. 2017 Apr;76(4):760-761
pubmed: 28325395
Lasers Surg Med. 2015 Feb;47(2):203-9
pubmed: 25727552
J Immunol. 2004 Feb 1;172(3):1848-55
pubmed: 14734769
J Allergy Clin Immunol. 2016 Jul;138(1):169-178
pubmed: 26948076
J Surg Res. 2003 Aug;113(2):208-16
pubmed: 12957131
Aesthetic Plast Surg. 2009 May;33(3):409-12
pubmed: 19357910
Aesthetic Plast Surg. 2011 Oct;35(5):802-7
pubmed: 21455826
Lasers Surg Med. 2021 Jan;53(1):66-69
pubmed: 33238039
Open Access Maced J Med Sci. 2019 Aug 30;7(18):2979-2981
pubmed: 31850103
Zhonghua Shao Shang Za Zhi. 2015 Jun;31(3):177-80
pubmed: 26564563
Int J Dermatol. 2001 May;40(5):349-53
pubmed: 11555001
Dermatol Surg. 2004 Jul;30(7):987-94; discussion 994
pubmed: 15209788
Int J Dermatol. 2021 Jun;60(6):661-671
pubmed: 32905614
J Eur Acad Dermatol Venereol. 2020 Apr;34(4):e161-e164
pubmed: 31747457
Acta Derm Venereol. 2018 Jan 12;98(1):121-122
pubmed: 28972247
Arch Orthop Trauma Surg. 2014 Apr;134(4):555-9
pubmed: 24509938
Dermatology. 2002;204(2):130-2
pubmed: 11937738
Acta Derm Venereol. 2017 Feb 8;97(2):225-229
pubmed: 27378582
J Cutan Laser Ther. 2000 Sep;2(3):147-50
pubmed: 11360332
Dermatol Reports. 2020 Oct 22;12(2):8312
pubmed: 33408828
Acta Derm Venereol. 2004;84(5):375-80
pubmed: 15370704
J Cosmet Dermatol. 2008 Mar;7(1):43-9
pubmed: 18254811
Histol Histopathol. 2015 Sep;30(9):1033-57
pubmed: 25900252
Plast Reconstr Surg Glob Open. 2015 Jul 08;3(6):e437
pubmed: 26180738
Dermatol Clin. 1988 Jul;6(3):413-24
pubmed: 3048824
Aesthetic Plast Surg. 2008 Mar;32(2):389-92
pubmed: 18185952
Aesthetic Plast Surg. 2008 Jan;32(1):82-92
pubmed: 17968615
Br J Dermatol. 2018 Apr;178(4):940-950
pubmed: 29194570
Dermatol Surg. 2008 Feb;34(2):184-94; discussion 194-5
pubmed: 18230115
J Burn Care Rehabil. 1987 Mar-Apr;8(2):126-31
pubmed: 3647037
Am J Pathol. 2015 Jun;185(6):1638-48
pubmed: 25871534
Am J Transl Res. 2020 Feb 15;12(2):574-582
pubmed: 32194905
Br J Cancer. 1993 Mar;67(3):545-50
pubmed: 7679921
Front Immunol. 2014 Nov 28;5:614
pubmed: 25506346
J Am Acad Dermatol. 2004 Dec;51(6):1002-6
pubmed: 15583600
Int J Dermatol. 2019 Oct;58(10):1135-1140
pubmed: 31429935
J Plast Surg Hand Surg. 2019 Oct;53(5):288-294
pubmed: 31066603
Front Immunol. 2020 Nov 23;11:597741
pubmed: 33329590
J Dermatolog Treat. 2003 Dec;14(4):248-52
pubmed: 14660274
Br J Dermatol. 2008 Mar;158(3):651-2
pubmed: 18205867
J Plast Reconstr Aesthet Surg. 2008 Oct;61(10):1219-25
pubmed: 18653391
Rheumatology (Oxford). 2020 Sep 1;59(9):2625-2636
pubmed: 32365362
Acta Derm Venereol. 2016 Feb;96(2):157-61
pubmed: 26073701
Cytokine Growth Factor Rev. 2003 Oct;14(5):369-74
pubmed: 12948520
Br J Dermatol. 2012 Nov;167(5):1053-66
pubmed: 23106354
Arch Dermatol Res. 2020 Mar;312(2):81-92
pubmed: 31493000
Acta Derm Venereol. 2012 Sep;92(5):529-31
pubmed: 22378106
Clin Cosmet Investig Dermatol. 2018 Jul 24;11:387-396
pubmed: 30087573
J Cosmet Dermatol. 2019 Jun;18(3):874-878
pubmed: 29935013