Impact of red blood cell distribution width and mean platelet volume in patients with ST-segment elevation myocardial infarction.


Journal

Heart and vessels
ISSN: 1615-2573
Titre abrégé: Heart Vessels
Pays: Japan
ID NLM: 8511258

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 08 05 2021
accepted: 03 09 2021
pubmed: 15 9 2021
medline: 7 4 2022
entrez: 14 9 2021
Statut: ppublish

Résumé

The complete blood cell count is one of the most frequently ordered laboratory tests, and many parameters, including red blood cell distribution width (RDW) and mean platelet volume (MPV), are available. The purpose of this study was to investigate the usefulness of the combination of RDW and MPV in patients with ST-segment elevation myocardial infarction (STEMI). Patients with STEMI who underwent primary percutaneous coronary intervention were retrospectively enrolled (n = 229). The association between RDW as well as MPV and cardiovascular events was investigated. The median age was 67 years, and males made up 85% of the sample. Median RDW was 13.6%, and median MPV was 8.2 fL. During a median follow-up period of 528 days (IQR 331.5-920.5), 41 patients died or experienced major adverse cardiac and cerebrovascular events (MACCEs). Patients with RDW ≧ 13.7% had more deaths or MACCEs with marginal significance (p = 0.0799). Patients with MPV ≧ 8.3 fL had significantly more deaths or MACCEs (p = 0.0283). Patients with RDW ≧ 13.7% and MPV ≧ 8.3 fL had significantly more deaths or MACCEs (p = 0.0185). MPV was significantly associated with death or adverse events in patients with STEMI who were treated with primary PCI. RDW had only a weak association with death or adverse events. The results of the combination of MPV and RDW were similar to those of MPV.

Identifiants

pubmed: 34518907
doi: 10.1007/s00380-021-01936-6
pii: 10.1007/s00380-021-01936-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

392-399

Informations de copyright

© 2021. Springer Japan KK, part of Springer Nature.

Références

Danese E, Lippi G, Montagnana M (2015) Red blood cell distribution width and cardiovascular diseases. J Thorac Dis 7:E402–E411
pubmed: 26623117 pmcid: 4635283
Imai R, Uemura Y, Okumura T, Takemoto T, Uchikawa T, Koyasu M, Ishikawa S, Iwamiya S, Ozaki Y, Shibata R, Watarai M, Murohara T (2017) Impact of red blood cell distribution width on non-cardiac mortality in patients with acute decompensated heart failure with preserved ejection fraction. J Cardiol 70:591–597
doi: 10.1016/j.jjcc.2017.03.010
Bujak K, Wasilewski J, Osadnik T, Jonczyk S, Kolodziejska A, Gierlotka M, Gasior M (2015) The prognostic role of red blood cell distribution width in coronary artery disease: a review of the pathophysiology. Dis Markers. https://doi.org/10.1155/2015/824624
doi: 10.1155/2015/824624 pubmed: 26379362 pmcid: 4563066
Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A (2014) Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol 175:433–440
doi: 10.1016/j.ijcard.2014.06.028
Choi D-H, Kang S-H, Song H (2016) Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease. Korean J Intern Med 31:1009–1017
doi: 10.3904/kjim.2016.078
Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelbloom JW, Konkle B, Mohler ER, Reilly MP, Berger JS (2010) Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 8:148–156
doi: 10.1111/j.1538-7836.2009.03584.x
Alvitigala BY, Azra MAF, Kottahachchi DU, Jayasekera MMPT, Wijesinghe RANK (2018) A study of association between platelet volume indices and ST elevation myocardial infarction. Int J Cardiol Heart Vasc 21:7–10
pubmed: 30211294 pmcid: 6134176
Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A, on behalf of the collaborators developing the Japanese equation for estimated GFR (2009) Revised equations for estimated GFR from serum creatinine in Japan. Am J Kid Dis 53:982–992
doi: 10.1053/j.ajkd.2008.12.034
May JE, Marques MB, Reddy VVB, Gangaraju R (2019) Three neglected numbers in the CBC: The RDW, MPV, and NRBC count. Cleveland Clinic J Med 86:167–172
doi: 10.3949/ccjm.86a.18072
Budzianowski J, Pieszko K, Burchardt P, Rzeźniczak J, Hiczkiewicz J (2017) The role of hematological indices in patients with acute coronary syndrome. Dis Markers. https://doi.org/10.1155/2017/3041565
doi: 10.1155/2017/3041565 pubmed: 29109595 pmcid: 5646322
Celik T, Kaya MG, Akpek M, Gunebakmaz O, Balta S, Sarli B, Duran M, Demirkol S, Uysal OK, Oguzhan A, Gibson CM (2015) Predictive value of admission platelet volume indices for in-hospital major adverse cardiovascular events in acute ST-segment elevation myocardial infarction. Angiology 66:155–162
doi: 10.1177/0003319713513493
Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkiwski R, Wilczynska J, Zielinski A, Meier B, Opolski G (2005) Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 46:284–290
doi: 10.1016/j.jacc.2005.03.065
Lekston A, Hudzik B, Hawranek M, Szkodzinski J, Gorol J, Wilczek K, Gasior M, Polonski L (2014) Prognostic significance of mean platelet volume in diabetic patients with ST-elevation myocardial infarction. J Diabetes Compl 28:652–657
doi: 10.1016/j.jdiacomp.2014.05.002
Haybar H, Pezeshki SMS, Saki N (2019) Evaluation of complete blood count parameters in cardiovascular diseases: an early indicator or prognosis? Exp Mol Pathol. https://doi.org/10.1016/j.yexmp.2019.104267
doi: 10.1016/j.yexmp.2019.104267 pubmed: 31194963
Wang X-Y, Yu H-Y, Zhang Y-Y, Wang Y-P, Feng X-H, Li Z-P, Du X-J, Gao W (2015) Serial changes of mean platelet volume in relation to Killip class in patients with acute myocardial infarction and primary percutaneous coronary intervention. Thromb Res 135:652–658
doi: 10.1016/j.thromres.2015.01.033
Grabovac ZS, Baković D, Lozo M, Pintarić I, Dujić Ž (2017) Early changes in platelet size and number in patients with acute coronary syndrome. Int J Angiol 26:249–252
doi: 10.1055/s-0037-1607048
De Luca G, Secco GG, Iorio S, Verdoia M, Bellomo G, Marino P (2012) Short-term effects of aspirin and clopidogrel on mean platelet volume among patients with acute coronary syndromes. A single-center prospective study. Blood Coagul Fibrinolysis 23:756–759
doi: 10.1097/MBC.0b013e328358e941
Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP, Van de Werf F, Avezum Á, Goodman SG, Flather MD, Fox KAA, Global Registry of Acute Coronary Events Investigators (2003) Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med 163:2345–2353
doi: 10.1001/archinte.163.19.2345
Eagle KA, Lim MJ, Dabbous OH, Pieper KS, Goldberg RJ, Van de Werf F, Goodman SG, Granger CB, Steg PG, Gore JM, Budaj A, Avezum Á, Flather MD, Fox KAA, the GRACE Investigators (2004) A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6 month postdischarge death in an international registry. JAMA 291:2727–2733
doi: 10.1001/jama.291.22.2727
Wan Z-F, Zhou D, Xue J-H, Wu Y, Wang H, Zhao Y, Zhu L, Yuan Z-Y (2014) Combination of mean platelet volume and the GRACE risk score better predicts future cardiovascular events in patients with acute coronary syndrome. Platelets 25:447–451
doi: 10.3109/09537104.2013.830708
Niu X, Yang C, Zhang Y, Zhang H, Yao Y (2015) Mean platelet volume on admission improves risk prediction in patients with acute coronary syndromes. Angiology 66:456–463
doi: 10.1177/0003319714536024
Isik T, Kurt M, Ayhan E, Tanboga IH, Ergelen M, Uyarel H (2012) The impact of admission red cell distribution width on the development of poor myocardial perfusion after primary percutaneous intervention. Atherosclerosis 224:143–149
doi: 10.1016/j.atherosclerosis.2012.06.017
Uyarel H, Ergelen M, Cicek G, Kaya MG, Ayhan E, Turkkan C, Yildirim E, Kirbas V, Onturk ET, Erer HB, Yesilcimen K, Gibson CM (2011) Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for myocardial infarction. Coron Artery Dis 22:138–144
doi: 10.1097/MCA.0b013e328342c77b
Abrahan LL, Ramos JDA, Cunanan EL, Tiongson MDA, Punzalan FER (2018) Red cell distribution width and mortality in patients with acute coronary syndrome: a meta-analysis on prognosis. Cardiol Res 9:144–152
doi: 10.14740/cr732w
Lippi G, Filippozzi L, Montagnana M, Salvagno GL, Franchini M, Guidi GC, Targher G (2009) Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes. Clin Chem Lab Med 47:353–357
pubmed: 19676148
Yčas JW, Horrow JC, Horne BD (2015) Persistent increase in red cell size distribution width after acute diseases: a biomarker of hypoxemia? Clin Chim Acta 448:107–117
doi: 10.1016/j.cca.2015.05.021

Auteurs

Toshiaki Ebina (T)

Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan. tebina@yokohama-cu.ac.jp.

Shiori Tochihara (S)

Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Mai Okazaki (M)

Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Kazuyo Koike (K)

Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Yuko Tsuto (Y)

Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Megumi Tayama (M)

Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Yukiko Takanami (Y)

Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Haruka Hirose (H)

Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Mutsuo Horii (M)

Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.
Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

Kozo Okada (K)

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

Yasushi Matsuzawa (Y)

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

Nobuhiko Maejima (N)

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

Noriaki Iwahashi (N)

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

Kiyoshi Hibi (K)

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

Masami Kosuge (M)

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

Kouichi Tamura (K)

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Kazuo Kimura (K)

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

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