Tumor organoids for cancer research and personalized medicine.
Organoids
cancer research
clinical cancer therapy
heterogeneity
personalized medicine
Journal
Cancer biology & medicine
ISSN: 2095-3941
Titre abrégé: Cancer Biol Med
Pays: China
ID NLM: 101588850
Informations de publication
Date de publication:
14 Sep 2021
14 Sep 2021
Historique:
entrez:
14
9
2021
pubmed:
15
9
2021
medline:
15
9
2021
Statut:
aheadofprint
Résumé
Organoids are three-dimensional culture systems generated from embryonic stem cells, induced pluripotent stem cells, and adult stem cells. They are capable of cell proliferation, differentiation, and self-renewal. Upon stimulation by signal factors and/or growth factors, organoids self-assemble to replicate the morphological and structural characteristics of the corresponding organs. They provide an extraordinary platform for investigating organ development and mimicking pathological processes. Organoid biobanks derived from a wide range of carcinomas have been established to represent different lesions or stages of clinical tumors. Importantly, genomic and transcriptomic analyses have confirmed maintenance of intra- and interpatient heterogeneities in organoids. Therefore, this technology has the potential to revolutionize drug screening and personalized medicine. In this review, we summarized the characteristics and applications of organoids in cancer research by the establishment of organoid biobanks directly from tumor organoids or from genetically modified non-cancerous organoids. We also analyzed the current state of organoid applications in drug screening and personalized medicine.
Identifiants
pubmed: 34520134
pii: j.issn.2095-3941.2021.0335
doi: 10.20892/j.issn.2095-3941.2021.0335
pmc: PMC8958892
doi:
pii:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31671421
Organisme : National Natural Science Foundation of China
ID : 82030079
Organisme : National Natural Science Foundation of China
ID : 82003187
Informations de copyright
Copyright © 2021 Cancer Biology & Medicine.
Déclaration de conflit d'intérêts
No potential conflicts of interest are disclosed.
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