Comparison of revised EWGSOP2 criteria of sarcopenia in patients with cancer using different parameters of muscle mass.
Aged
Algorithms
Anthropometry
Brazil
/ epidemiology
Cross-Sectional Studies
Female
Hand Strength
Humans
Lumbar Vertebrae
/ diagnostic imaging
Male
Medical Oncology
/ standards
Middle Aged
Muscle, Skeletal
/ physiopathology
Neoplasms
/ complications
Predictive Value of Tests
Prevalence
Sarcopenia
/ complications
Sensitivity and Specificity
Tomography, X-Ray Computed
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
10
2020
accepted:
01
09
2021
entrez:
14
9
2021
pubmed:
15
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Calf circumference (CC) has been established as a marker of muscle mass (MM) with good performance for predicting survival in individuals with cancer. The study aims to determine the prevalence of sarcopenia according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria and to evaluate the accuracy of sarcopenia using low CC relative to MM assessment by computed tomography (CT) at third lumbar vertebra level (L3) as a reference. Cross-sectional study with cancer patients aged ≥ 60 years. Data included socio-demographic, clinical and anthropometric variables. MM was assessed by CC and by CT images at the L3. Sarcopenia was diagnosed according to the EWGSOP2 criteria: a) low handgrip strength (HGS) + reduced MM evaluated by CT; and b) low HGS + low CC. Pearson's correlation, accuracy, sensitivity, specificity, positive predictive and negative predictive value were analyzed. A total of 108 patients were evaluated, age of 70.6 ± 7.4 years (mean ± standard deviation). The prevalence of sarcopenia was of 24.1% (low MM) and 25.9% (low CC). The Kappa test showed a substantial agreement (K = 0.704), 81% sensitivity, and 92% specificity. Although the EWGSOP2 advises that we should use CC measures in the algorithm for sarcopenia when no other MM diagnostic methods are available, the findings allow the use of CC instead of MM by CT in cancer patients.
Identifiants
pubmed: 34520502
doi: 10.1371/journal.pone.0257446
pii: PONE-D-20-33755
pmc: PMC8439478
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0257446Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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