Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women.
Bone density
Collagen
DXA
Osteoporosis
Peptides
Journal
Journal of bone metabolism
ISSN: 2287-6375
Titre abrégé: J Bone Metab
Pays: Korea (South)
ID NLM: 101599927
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
27
04
2021
accepted:
30
06
2021
entrez:
14
9
2021
pubmed:
15
9
2021
medline:
15
9
2021
Statut:
ppublish
Résumé
The effects of specific collagen peptides on bone mineral density (BMD) in subjects with osteoporosis or osteopenia have already been investigated in 131 postmenopausal women in a randomized controlled trial. The purpose of this follow-up observation was to determine the longer-term effects of the same specific bioactive collagen peptides after a total intervention time of 4 years. In this open-label follow-up observation, 31 postmenopausal women with reduced BMD (initial T-score lower than-1 of either the femoral neck or the lumbar spine) completed the follow-up. BMD was measured via dual energy X-ray absorptiometry. Absolute changes in BMD and T-scores in the spine and femoral neck were assessed. The number of fractures was also recorded. All participants received specific bioactive collagen peptides. Supplementation with bioactive collagen peptides during follow-up led to a clinically relevant increase in BMD in the spine. These findings were consistent with the results for the femoral neck. Long-term supplementation with specific bioactive collagen peptides appears to be effective in counteracting losses in BMD. Moreover, significant increases in BMD could contribute to improved bone stability.
Sections du résumé
BACKGROUND
BACKGROUND
The effects of specific collagen peptides on bone mineral density (BMD) in subjects with osteoporosis or osteopenia have already been investigated in 131 postmenopausal women in a randomized controlled trial. The purpose of this follow-up observation was to determine the longer-term effects of the same specific bioactive collagen peptides after a total intervention time of 4 years.
METHODS
METHODS
In this open-label follow-up observation, 31 postmenopausal women with reduced BMD (initial T-score lower than-1 of either the femoral neck or the lumbar spine) completed the follow-up. BMD was measured via dual energy X-ray absorptiometry. Absolute changes in BMD and T-scores in the spine and femoral neck were assessed. The number of fractures was also recorded. All participants received specific bioactive collagen peptides.
RESULTS
RESULTS
Supplementation with bioactive collagen peptides during follow-up led to a clinically relevant increase in BMD in the spine. These findings were consistent with the results for the femoral neck.
CONCLUSIONS
CONCLUSIONS
Long-term supplementation with specific bioactive collagen peptides appears to be effective in counteracting losses in BMD. Moreover, significant increases in BMD could contribute to improved bone stability.
Identifiants
pubmed: 34520654
pii: jbm.2021.28.3.207
doi: 10.11005/jbm.2021.28.3.207
pmc: PMC8441532
doi:
Types de publication
Journal Article
Langues
eng
Pagination
207-213Subventions
Organisme : GELITA GmbH
Références
Osteoporos Int. 2006 Dec;17(12):1726-33
pubmed: 16983459
Osteoporos Int. 2005 Dec;16(12):2031-8
pubmed: 16088360
J Med Food. 2015 Mar;18(3):324-31
pubmed: 25314004
N Engl J Med. 1995 Nov 30;333(22):1437-43
pubmed: 7477143
BMJ Open. 2019 Apr 14;9(4):e027049
pubmed: 30987990
J Steroid Biochem Mol Biol. 2014 Jul;142:155-70
pubmed: 24176761
Crit Rev Food Sci Nutr. 2017 Jun 13;57(9):1922-1937
pubmed: 25976422
J Dermatol. 2010 Apr;37(4):330-8
pubmed: 20507402
Molecules. 2013 Dec 12;18(12):15474-89
pubmed: 24352008
Sports Med. 2009;39(6):439-68
pubmed: 19453205
Cas Lek Cesk. 1996 Jan 31;135(3):74-8
pubmed: 8625373
J Clin Endocrinol Metab. 2008 Mar;93(3):861-8
pubmed: 18160467
World Health Organ Tech Rep Ser. 2003;921:1-164, back cover
pubmed: 15293701
Wien Med Wochenschr. 2015 Feb;165(3-4):54-64
pubmed: 25502850
Osteoarthritis Cartilage. 2009 Dec;17(12):1620-7
pubmed: 19615963
Nutrients. 2018 Jan 16;10(1):
pubmed: 29337906
Osteoarthritis Cartilage. 2011 Apr;19(4):399-405
pubmed: 21251991
Osteoporos Int. 2013 Jan;24(1):23-57
pubmed: 23079689
Cell Tissue Res. 2003 Mar;311(3):393-9
pubmed: 12658447
Postgrad Med J. 2003 Jun;79(932):320-3
pubmed: 12840119
J Biochem. 2001 Jan;129(1):133-8
pubmed: 11134967
J Agric Food Chem. 2010 Jan 27;58(2):835-41
pubmed: 19957932
Ann Biomed Eng. 2007 Nov;35(11):1914-23
pubmed: 17721729
Curr Opin Clin Nutr Metab Care. 2014 Jan;17(1):69-74
pubmed: 24316688
J Clin Densitom. 2005 Winter;8(4):371-8
pubmed: 16311420