Hypoxia-activated platelets stimulate proliferation and migration of pulmonary arterial smooth muscle cells by phosphatidylserine/LOX-1 signaling-impelled intercellular communication.
Cell migration
Cell proliferation
Hypoxia
Lectin like oxidized low-density lipoprotein receptor-1
Platelets
Pulmonary arterial smooth muscle cells
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
25
06
2021
revised:
23
08
2021
accepted:
09
09
2021
pubmed:
15
9
2021
medline:
1
4
2022
entrez:
14
9
2021
Statut:
ppublish
Résumé
Continuous recruitment and inappropriate activation of platelets in pulmonary arteries contribute to pulmonary vascular remodeling in pulmonary hypertension (PH). Our previous study has demonstrated that lectin like oxidized low-density lipoprotein receptor-1 (LOX-1) regulates the proliferation of pulmonary arterial smooth muscle cells (PASMCs). Phosphatidylserine exposed on the surface of activated platelets is a ligand for LOX-1. However, whether hypoxia-activated platelets stimulate the proliferation and migration of PASMCs by phosphatidylserine/LOX-1 signaling-impelled intercellular communication remains unclear. The present study found that rats treated with hypoxia (10% O
Identifiants
pubmed: 34520855
pii: S0898-6568(21)00238-2
doi: 10.1016/j.cellsig.2021.110149
pii:
doi:
Substances chimiques
Phosphatidylserines
0
Scavenger Receptors, Class E
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110149Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.