A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury.
Journal
Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
09
04
2021
accepted:
04
08
2021
pubmed:
15
9
2021
medline:
9
11
2021
entrez:
14
9
2021
Statut:
ppublish
Résumé
Traumatic spinal cord injuries (SCIs) have far-reaching physical, social, and financial consequences. While medical advancements have improved supportive therapeutic measures for SCI patients, no effective neuroregenerative therapeutic options exist to date. Instead, the paradigm of SCI therapy is inevitably directed towards damage control rather than the restoration of a state of functional independence. Facing a continuous increase in the prevalence of spinal cord injured patients, neuroprotective and neuroregenerative strategies have earned tremendous scientific interest. This review intends to provide a robust summary of the most promising neuroprotective and neuroregenerative therapies currently under investigation. While we highlight encouraging neuroprotective strategies as well, the focus of this review lies on neuroregenerative therapies, including neuropharmacological and cell-based approaches. We finally point to the exciting investigational areas of biomaterial scaffolds and neuromodulation therapies.
Identifiants
pubmed: 34520943
pii: S1471-4892(21)00130-2
doi: 10.1016/j.coph.2021.08.009
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
331-340Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.