Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.
Adipogenesis
Developmentally regulated GTP-Binding protein 2 (DRG2)
Lipid metabolism
Obesity
Peroxisome proliferator activated receptor-γ (PPAR-γ)
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
12 11 2021
12 11 2021
Historique:
received:
03
08
2021
accepted:
27
08
2021
pubmed:
15
9
2021
medline:
29
1
2022
entrez:
14
9
2021
Statut:
ppublish
Résumé
Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2. Consistent with these results, DRG2 Tg mice showed increased expression of genes involved in adipogenesis and lipid metabolism in the white adipose tissue. DRG2 was also identified to control adipogenesis by cooperating with peroxisome proliferator activated receptor-γ (PPAR-γ) in cultured adipocytes. Overall, the findings of the current study suggest that DRG2 plays an active role in regulating adipocyte differentiation, and thus participates in the development of obesity during exposure to a fat-rich diet.
Identifiants
pubmed: 34520979
pii: S0006-291X(21)01263-8
doi: 10.1016/j.bbrc.2021.08.081
pii:
doi:
Substances chimiques
DRG2 protein, human
0
PPAR gamma
0
Pparg protein, mouse
0
GTP-Binding Proteins
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-6Informations de copyright
Copyright © 2021. Published by Elsevier Inc.