The comparison of censored quantile regression methods in prognosis factors of breast cancer survival.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
14 09 2021
Historique:
received: 15 01 2021
accepted: 25 08 2021
entrez: 15 9 2021
pubmed: 16 9 2021
medline: 17 12 2021
Statut: epublish

Résumé

The Cox proportional hazards model is a widely used statistical method for the censored data that model the hazard rate rather than survival time. To overcome complexity of interpreting hazard ratio, quantile regression was introduced for censored data with more straightforward interpretation. Different methods for analyzing censored data using quantile regression model, have been introduced. The quantile regression approach models the quantile function of failure time and investigates the covariate effects in different quantiles. In this model, the covariate effects can be changed for patients with different risk and is a flexible model for controlling the heterogeneity of covariate effects. We illustrated and compared five methods in quantile regression for right censored data included Portnoy, Wang and Wang, Bottai and Zhang, Yang and De Backer methods. The comparison was made through the use of these methods in modeling the survival time of breast cancer. According to the results of quantile regression models, tumor grade and stage of the disease were identified as significant factors affecting 20th percentile of survival time. In Bottai and Zhang method, 20th percentile of survival time for a case with higher unit of stage decreased about 14 months and 20th percentile of survival time for a case with higher grade decreased about 13 months. The quantile regression models acted the same to determine prognostic factors of breast cancer survival in most of the time. The estimated coefficients of five methods were close to each other for quantiles lower than 0.1 and they were different from quantiles upper than 0.1.

Identifiants

pubmed: 34521936
doi: 10.1038/s41598-021-97665-x
pii: 10.1038/s41598-021-97665-x
pmc: PMC8440570
doi:

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

18268

Informations de copyright

© 2021. The Author(s).

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Auteurs

Akram Yazdani (A)

Department of Biostatistics and Epidemiology, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Mehdi Yaseri (M)

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Shahpar Haghighat (S)

Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.

Ahmad Kaviani (A)

Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.

Hojjat Zeraati (H)

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. zeraatih@tums.ac.ir.

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