Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons.
COPD
low-grade systemic inflammation
mCRP
pCRP
Journal
Journal of inflammation research
ISSN: 1178-7031
Titre abrégé: J Inflamm Res
Pays: New Zealand
ID NLM: 101512684
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
05
2021
accepted:
20
07
2021
entrez:
15
9
2021
pubmed:
16
9
2021
medline:
16
9
2021
Statut:
epublish
Résumé
Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.
Identifiants
pubmed: 34522118
doi: 10.2147/JIR.S320659
pii: 320659
pmc: PMC8434905
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4503-4507Informations de copyright
© 2021 Munuswamy et al.
Déclaration de conflit d'intérêts
Ms Revathy Munuswamy and Prof. Dr. Luc Michiels report a patent EP20212664 pending to Luc Michiels, UHasselt. The authors report no other conflicts of interest in this work.
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