Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions.
care systems
contact lenses
multipurpose solutions
preservatives
Journal
Clinical optometry
ISSN: 1179-2752
Titre abrégé: Clin Optom (Auckl)
Pays: New Zealand
ID NLM: 101730504
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
07
2021
accepted:
24
08
2021
entrez:
15
9
2021
pubmed:
16
9
2021
medline:
16
9
2021
Statut:
epublish
Résumé
Preservatives are essential for preventing contact lens (CL)-related microbial keratitis (MK). The purpose of this review is to summarize the current knowledge related to the use of common ophthalmic preservatives in CL care products with respect to both safety and efficacy. Manuscripts written in English were obtained by searching PubMed.gov with the term contact lens plus antimicrobial, benzalkonium chloride, biguanide, Aldox, polyquaternium, preservative, thimerosal, EDTA (ethylenediaminetetraacetic acid), chlorhexidine, or blister pack. This review found that first-generation preservatives are no longer used in CL multipurpose solutions (MPS) due to their high levels of ocular toxicity. Modern, high-molecular-weight preservatives, including polyquaternium-1 (PQ-1) and biguanides (PHMB), are generally effective against bacteria, minimally effective against fungi, and not effective against Patients should be monitored when using PQ-1 or PHMB-containing solutions since they have been associated with ocular adverse events. If events are detected, patients should be switched to an alternative solution. H
Identifiants
pubmed: 34522149
doi: 10.2147/OPTO.S235679
pii: 235679
pmc: PMC8434857
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
271-285Informations de copyright
© 2021 Bradley et al.
Déclaration de conflit d'intérêts
Dr. Lindsay A. Sicks reports personal fees and Honoraria (Speaker’s Alliance) from Alcon Laboratories outside the submitted work. Dr. Andrew D. Pucker has received financial research support from Alcon Research, LLC, Art Optical, Bausch & Lomb, Euclid Systems, Contamac, National Eye Institute, and Paragon Vision Sciences, and consulted for Alcon Research, LLC, CooperVision, EpiTech, EyeGate Pharmaceuticals, Inc, Kala Pharmaceuticals, Nevakar Inc, and Optikal Care Inc over the past three years. The authors report no other conflicts of interest in this work.
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