Liquid-liquid phase separation (LLPS) in cellular physiology and tumor biology.
Liquid-liquid phase separation
intrinsically disordered regions
membraneless condensates
modular domains
Journal
American journal of cancer research
ISSN: 2156-6976
Titre abrégé: Am J Cancer Res
Pays: United States
ID NLM: 101549944
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
02
2021
accepted:
20
04
2021
entrez:
15
9
2021
pubmed:
16
9
2021
medline:
16
9
2021
Statut:
epublish
Résumé
Liquid-liquid phase separation (LLPS) has emerged as a mechanism that has been used to explain the formation of known organelles (e.g. nucleoli, promyelocytic leukemia nuclear bodies (PML NBs), etc) as well as other membraneless condensates (e.g. nucleosome arrays, DNA damage foci, X-chromosome inactivation (XCI) center, paraspeckles, stress granules, proteasomes, autophagosomes, etc). The formation of membraneless condensates could be triggered by proteins containing modular domains or intrinsically disordered regions (IDRs) and nucleic acids. Multiple biological processes including transcription, chromatin organization, X-chromosome inactivation (XCI), DNA damage, tumorigenesis, autophagy, etc have been shown to utilize the principle of LLPS to facilitate these processes. This review will summarize the principle and components of LLPS, and describe how LLPS regulate these numerous biological processes and disruption of LLPS would cause disease formation. The role of LLPS in regulating normal cellular physiology and contributing to tumorigenesis will be discussed.
Types de publication
Journal Article
Review
Langues
eng
Pagination
3766-3776Informations de copyright
AJCR Copyright © 2021.
Déclaration de conflit d'intérêts
None.
Références
Nature. 2012 Mar 07;483(7389):336-40
pubmed: 22398450
Mol Cell. 2015 Mar 5;57(5):936-947
pubmed: 25747659
Nat Struct Mol Biol. 2019 May;26(5):331-334
pubmed: 31061525
Methods. 2004 Nov;34(3):266-72
pubmed: 15325646
Nat Rev Mol Cell Biol. 2017 May;18(5):285-298
pubmed: 28225081
Cell. 2019 Oct 3;179(2):470-484.e21
pubmed: 31543265
Cell. 2018 Dec 13;175(7):1842-1855.e16
pubmed: 30449618
Science. 2018 Jul 27;361(6400):412-415
pubmed: 29930094
Science. 2017 Sep 22;357(6357):
pubmed: 28935776
Cell. 2020 Apr 16;181(2):346-361.e17
pubmed: 32302572
Science. 2018 Jan 5;359(6371):
pubmed: 29301985
Cell. 2018 Aug 23;174(5):1172-1187.e16
pubmed: 30078712
Science. 2020 Jun 19;368(6497):1386-1392
pubmed: 32554597
Cell. 2020 Apr 16;181(2):325-345.e28
pubmed: 32302571
Nature. 2017 Jun 8;546(7657):243-247
pubmed: 28562589
Cell Res. 2018 Apr;28(4):405-415
pubmed: 29507397
Cancer Sci. 2020 Sep;111(9):3155-3163
pubmed: 32594560
Nucleic Acids Res. 2020 Nov 4;48(19):10953-10972
pubmed: 33045735
Nature. 2017 Jul 13;547(7662):241-245
pubmed: 28636597
Cell. 2020 Oct 15;183(2):490-502.e18
pubmed: 33002410
Science. 1899 Jul 14;10(237):33-45
pubmed: 17829686
Science. 2018 Jul 27;361(6400):
pubmed: 29930091
Mol Cell. 2018 Mar 15;69(6):965-978.e6
pubmed: 29526694
Nature. 2017 Jul 13;547(7662):236-240
pubmed: 28636604
Mol Cell. 2018 Oct 4;72(1):19-36.e8
pubmed: 30244836
Science. 2020 Feb 7;367(6478):694-699
pubmed: 32029630
Sci China Life Sci. 2020 Jul;63(7):953-985
pubmed: 32548680
Nature. 2020 Nov;587(7832):145-151
pubmed: 32908311
Cell. 2016 Jul 28;166(3):651-663
pubmed: 27374333
Mol Cell. 2015 Oct 15;60(2):208-19
pubmed: 26412307
Cell. 2019 Jan 24;176(3):419-434
pubmed: 30682370
Nat Cell Biol. 2019 Oct;21(10):1286-1299
pubmed: 31570834
Nature. 2020 Dec;588(7838):454-458
pubmed: 33208945
Nat Commun. 2020 Mar 6;11(1):1229
pubmed: 32144274
Nat Rev Mol Cell Biol. 2021 Mar;22(3):165-182
pubmed: 32873929
Mol Cell. 2016 Jul 7;63(1):72-85
pubmed: 27392146
Cell. 2017 Jun 1;169(6):1066-1077.e10
pubmed: 28575670
Cell. 2018 Jul 26;174(3):688-699.e16
pubmed: 29961577
Nat Cell Biol. 2020 Oct;22(10):1187-1196
pubmed: 32929202
Nat Cell Biol. 2020 Apr;22(4):453-464
pubmed: 32203417
Nucleic Acids Res. 2020 Dec 2;48(21):11890-11912
pubmed: 33068409
Cell. 2017 Mar 9;168(6):1028-1040.e19
pubmed: 28283059
Cell. 2018 May 3;173(4):946-957.e16
pubmed: 29576456
Nature. 2019 Sep;573(7772):144-148
pubmed: 31435012
Nature. 2020 Feb;578(7794):296-300
pubmed: 32025036
Science. 2018 Aug 17;361(6403):704-709
pubmed: 29976794
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4334-9
pubmed: 21368180
Mol Cell. 2018 Jun 21;70(6):1038-1053.e7
pubmed: 29932899