Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs.
Cancer
Clinic
Diabetes
Infectious diseases
Microneedles
Peptides
Proteins
Transdermal drug delivery
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
23
08
2020
revised:
12
11
2020
accepted:
08
12
2020
entrez:
15
9
2021
pubmed:
16
9
2021
medline:
16
9
2021
Statut:
ppublish
Résumé
Proteins and peptides have become a significant therapeutic modality for various diseases because of their high potency and specificity. However, the inherent properties of these drugs, such as large molecular weight, poor stability, and conformational flexibility, make them difficult to be formulated and delivered. Injection is the primary route for clinical administration of protein and peptide drugs, which usually leads to poor patient's compliance. As a portable, minimally invasive device, microneedles (MNs) can overcome the skin barrier and generate reversible microchannels for effective macromolecule permeation. In this review, we highlighted the recent advances in MNs-mediated transdermal delivery of protein and peptide drugs. Emphasis was given to the latest development in representative MNs design and fabrication. We also summarize the current application status of MNs-mediated transdermal protein and peptide delivery, especially in the field of infectious disease, diabetes, cancer, and other disease therapy. Finally, the current status of clinical translation and a perspective on future development are also provided.
Identifiants
pubmed: 34522590
doi: 10.1016/j.apsb.2021.03.003
pii: S2211-3835(21)00074-5
pmc: PMC8424228
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2326-2343Informations de copyright
© 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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