Duration of carriage of multidrug-resistant bacteria in dogs and cats in veterinary care and co-carriage with their owners.
3GC-R, Third Generation Cephalosporin-resistant
3GC-R-Ent., Third Generation Cephalosporin-resistant Enterobacterales
AMR, Antimicrobial resistance
CI, Confidence interval
CLSI, Clinical and Laboratory Standards Institute
COL-R, Colistin-resistant
CP, Carbapenemase-producing
CR, Carbapenem-resistant
CRE, Carbapenem-resistant Enterobacterales
Carbapenemase-producing Enterobacterales
Co-carriage
Companion animal
ERIC-PCR, Enterobacterial repetitive intergenic consensus polymerase chain reaction
ESBL, Extended spectrum β-lactamase
ESBL-E. coli, ESBL-producing Escherichia coli
ESBL-KP, ESBL-producing Klebsiella pneumoniae
EUCAST, European Committee on Antimicrobial Susceptibility Testing
Extended-spectrum β-lactamase
IQR, Interquartile range
KP, Klebsiella pneumoniae
MALDI-TOF MS, Matrix-assisted laser desorption/ionization time of flight mass spectrometry
MDR, Multidrug-resistant
MDROs, Multidrug-resistant organisms
MICs, Minimal inhibitory concentrations
MLST, Multilocus sequence typing
MR, Methicillin-resistant
MRCoNS, Methicillin-resistant coagulase-negative staphylococci
MRSA, Methicillin-resistant Staphylococcus aureus
MRSP, Methicillin-resistant Staphylococcus pseudintermedius
REP-PCR, Repetitive element palindromic polymerase chain reaction
ST, Sequence type
TMP-S, Trimethoprim/sulfamethoxazole
Transmission
WGS, Whole-genome sequencing
pAmpC, Plasmid-encoded AmpC
Journal
One health (Amsterdam, Netherlands)
ISSN: 2352-7714
Titre abrégé: One Health
Pays: Netherlands
ID NLM: 101660501
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
01
04
2021
revised:
30
08
2021
accepted:
30
08
2021
entrez:
15
9
2021
pubmed:
16
9
2021
medline:
16
9
2021
Statut:
epublish
Résumé
The emergence and spread of multidrug-resistant organisms (MDROs) represent a threat to human and animal health. To assess duration of carriage of MDROs in dogs and cats presented to veterinary clinics/hospitals in Switzerland. To estimate prevalence, duration of and risk factors for MDRO carriage in their owners and the occurrence of co-carriage in owner-pet pairs. Prospective, longitudinal, observational study. Nasal swabs and fecal samples were collected from 50 owners of dogs and cats presented to 3 large veterinary hospitals, 1 medium-sized clinic and 1 practice. If pet or owner tested positive for a MDRO, follow-up samples were collected for up to 8 months. Methicillin-resistant (MR) Five out of 50 owners carried 3rd generation cephalosporin-resistant Enterobacterales (3GC-R-Ent.), and 5/50 MRCoNS. In 3 dogs and 4 cats carriage of 3GC-R-Ent. persisted for up to 136 days after discharge (median 99 days, IQR 83 days, range 36-136 days), in two cats isolates were carbapenem-resistant. Owner-pet co-carriage was not observed. No specific risk factors for MDRO carriage in owners were identified. After discharge from veterinary care, dogs and cats may carry 3GC-R-Ent. for prolonged time periods. Carriage of MDROs was common in owners, but pet-owner co-carriage of the same MDRO was not observed.
Sections du résumé
BACKGROUND
BACKGROUND
The emergence and spread of multidrug-resistant organisms (MDROs) represent a threat to human and animal health.
OBJECTIVES
OBJECTIVE
To assess duration of carriage of MDROs in dogs and cats presented to veterinary clinics/hospitals in Switzerland. To estimate prevalence, duration of and risk factors for MDRO carriage in their owners and the occurrence of co-carriage in owner-pet pairs.
METHODS
METHODS
Prospective, longitudinal, observational study. Nasal swabs and fecal samples were collected from 50 owners of dogs and cats presented to 3 large veterinary hospitals, 1 medium-sized clinic and 1 practice. If pet or owner tested positive for a MDRO, follow-up samples were collected for up to 8 months. Methicillin-resistant (MR)
RESULTS
RESULTS
Five out of 50 owners carried 3rd generation cephalosporin-resistant Enterobacterales (3GC-R-Ent.), and 5/50 MRCoNS. In 3 dogs and 4 cats carriage of 3GC-R-Ent. persisted for up to 136 days after discharge (median 99 days, IQR 83 days, range 36-136 days), in two cats isolates were carbapenem-resistant. Owner-pet co-carriage was not observed. No specific risk factors for MDRO carriage in owners were identified.
CONCLUSIONS
CONCLUSIONS
After discharge from veterinary care, dogs and cats may carry 3GC-R-Ent. for prolonged time periods. Carriage of MDROs was common in owners, but pet-owner co-carriage of the same MDRO was not observed.
Identifiants
pubmed: 34522760
doi: 10.1016/j.onehlt.2021.100322
pii: S2352-7714(21)00112-9
pmc: PMC8424212
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100322Informations de copyright
© 2021 The Authors. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
None.
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