Pharmacokinetically guided, once-daily intravenous busulfan in combination with fludarabine for elderly AML/MDS patients as a conditioning regimen for allogeneic stem cell transplantation.
Aged
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Area Under Curve
Busulfan
/ administration & dosage
Combined Modality Therapy
Disease Management
Drug Monitoring
Graft Survival
Graft vs Host Disease
/ etiology
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Leukemia, Myeloid, Acute
/ diagnosis
Male
Middle Aged
Myelodysplastic Syndromes
/ diagnosis
Palliative Care
Prognosis
Transplantation Conditioning
/ methods
Transplantation, Homologous
Treatment Outcome
Vidarabine
/ administration & dosage
Area under the curve
Busulfan
Conditioning
Pharmacokinetics
Transplant-related toxicity
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
29
01
2021
accepted:
29
06
2021
revised:
24
06
2021
pubmed:
16
9
2021
medline:
17
12
2021
entrez:
15
9
2021
Statut:
ppublish
Résumé
The efficacy of pharmacokinetically (PK) guided, once-daily administration of busulfan (BU) was evaluated in elderly patients with acute myeloid leukemia/myelodysplastic syndrome (AML/MDS). Twenty-one patients (median age 61) received 30 mg/m
Identifiants
pubmed: 34523110
doi: 10.1007/s12185-021-03188-6
pii: 10.1007/s12185-021-03188-6
doi:
Substances chimiques
Vidarabine
FA2DM6879K
Busulfan
G1LN9045DK
fludarabine
P2K93U8740
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
664-673Informations de copyright
© 2021. Japanese Society of Hematology.
Références
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