The Potential of Pancreatic Organoids for Diabetes Research and Therapy.
ALDH
CD133
LGR5
Organoids
PROCR
adult stem cells
beta cell
beta cell regeneration
diabetes
pancreas
progenitor cells
stem cell therapy
transplantation
Journal
Islets
ISSN: 1938-2022
Titre abrégé: Islets
Pays: United States
ID NLM: 101495366
Informations de publication
Date de publication:
03 09 2021
03 09 2021
Historique:
pubmed:
16
9
2021
medline:
16
11
2021
entrez:
15
9
2021
Statut:
ppublish
Résumé
The success of clinical transplantation of pancreas or isolated pancreatic islets supports the concept of cell-based cure for diabetes. One limitation is the shortage of cadaver human pancreata. The demand-supply gap could potentially be bridged by harnessing the self-renewal capacity of stem cells. Pluripotent stem cells and adult pancreatic stem cells have been explored as possible cell sources. Recently, a system for long-term culture of proposed adult pancreatic stem cells in a form of organoids was developed. Generated organoids partially mimic the architecture and cell-type composition of pancreatic tissue. Here, we review the attempts over the past decade, to utilize the organoid cell culture principles in order to identify, expand, and differentiate the adult pancreatic stem cells from different compartments of mouse and human pancreata. The development of the culture conditions, effects of specific growth factors and small molecules is discussed. The potential utility of the adult pancreatic stem cells is considered in the context of other cell sources.
Identifiants
pubmed: 34523383
doi: 10.1080/19382014.2021.1941555
pmc: PMC8528407
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-105Références
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