[Lithium use in women with bipolar disorder during peripartum].
Lithiumgebruik bij vrouwen met een bipolaire stoornis tijdens het peripartum overzichtsartikel.
Journal
Tijdschrift voor psychiatrie
ISSN: 0303-7339
Titre abrégé: Tijdschr Psychiatr
Pays: Netherlands
ID NLM: 0423731
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
15
9
2021
pubmed:
16
9
2021
medline:
18
9
2021
Statut:
ppublish
Résumé
Lithium use during peripartum requires careful consideration due to a risk of teratogenic effects, adverse side effects and risk of neonatal complications. However, given the effectiveness of lithium, use during the peripartum period may be indicated. To provide an overview of the current evidence regarding the clinical use of lithium during peripartum, including risk of relapse in case of (dis)continuation and evolution of lithium levels. A review was performed in the Medline and ScienceDirect database. Ten studies were included. Six studies concerned the risk of relapse in case of (dis)continuation of lithium during the peripartum. Four studies concerned the evolution of lithium levels throughout the peripartum. Lithium discontinuation during pregnancy leads to an increased risk of relapse during pregnancy and postpartum. At the same dose, lithium levels are lower than preconceptual in all trimesters. Risk and benefits of lithium use during the peripartum should be carefully considered, if possible prior to conception. Close monitoring of maternal lithium levels and renal function is necessary due to significant fluctuations during peripartum.
Sections du résumé
BACKGROUND
BACKGROUND
Lithium use during peripartum requires careful consideration due to a risk of teratogenic effects, adverse side effects and risk of neonatal complications. However, given the effectiveness of lithium, use during the peripartum period may be indicated.
AIM
OBJECTIVE
To provide an overview of the current evidence regarding the clinical use of lithium during peripartum, including risk of relapse in case of (dis)continuation and evolution of lithium levels.
METHOD
METHODS
A review was performed in the Medline and ScienceDirect database.
RESULTS
RESULTS
Ten studies were included. Six studies concerned the risk of relapse in case of (dis)continuation of lithium during the peripartum. Four studies concerned the evolution of lithium levels throughout the peripartum. Lithium discontinuation during pregnancy leads to an increased risk of relapse during pregnancy and postpartum. At the same dose, lithium levels are lower than preconceptual in all trimesters.
CONCLUSION
CONCLUSIONS
Risk and benefits of lithium use during the peripartum should be carefully considered, if possible prior to conception. Close monitoring of maternal lithium levels and renal function is necessary due to significant fluctuations during peripartum.
Substances chimiques
Lithium
9FN79X2M3F
Types de publication
Journal Article
Review
Langues
dut
Sous-ensembles de citation
IM