Isolated diastolic hypertension and target organ damage: Findings from the STANISLAS cohort.
ambulatory blood pressure
isolated diastolic hypertension
target organ damage
Journal
Clinical cardiology
ISSN: 1932-8737
Titre abrégé: Clin Cardiol
Pays: United States
ID NLM: 7903272
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
02
08
2021
received:
18
06
2021
accepted:
05
08
2021
pubmed:
16
9
2021
medline:
10
11
2021
entrez:
15
9
2021
Statut:
ppublish
Résumé
Isolated diastolic hypertension (IDH) is defined as diastolic blood pressure (DBP) ≥80 mmHg and systolic blood pressure (SBP) <130 mmHg according to 2017 ACC/AHA guidelines. The effective cardiovascular risk linked to IDH is debated. IDH might contribute marginally to hypertension-related target organ damage (TOD) development. In this cross-sectional analysis 1605 subjects from the STANISLAS cohort, a large familiar longitudinal study from Eastern France, were included. Participants were categorized according to average values at 24-h ABP recording as having normal BP (SBP < 130/DBP < 80 mmHg); combined hypertension (SBP ≥130/DBP ≥80 mmHg or on antihypertensive treatment); IDH (SBP <130/DBP >80 mmHg); isolated systolic hypertension (ISH: SBP ≥130/DBP <80 mmHg). The association between hypertension status and TOD was assessed by multivariable-adjusted logistic models. Using normotension as reference, IDH was not significantly associated with NTproBNP levels (adjusted odds ratio [OR] 1.04 [95%CI 0.82;1.32], p = .750), microalbuminuria (OR 0.99 [0.69; 1.42], p = .960), diastolic dysfunction (OR 1.53 [0.88; 2.68], p = .130), left ventricular (LV) mass index (OR per 10 g/m IDH was not significantly associated with TOD. Further studies are needed to clarify the clinical role of IDH. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01391442.
Sections du résumé
BACKGROUND
BACKGROUND
Isolated diastolic hypertension (IDH) is defined as diastolic blood pressure (DBP) ≥80 mmHg and systolic blood pressure (SBP) <130 mmHg according to 2017 ACC/AHA guidelines. The effective cardiovascular risk linked to IDH is debated.
HYPOTHESIS
OBJECTIVE
IDH might contribute marginally to hypertension-related target organ damage (TOD) development.
METHODS
METHODS
In this cross-sectional analysis 1605 subjects from the STANISLAS cohort, a large familiar longitudinal study from Eastern France, were included. Participants were categorized according to average values at 24-h ABP recording as having normal BP (SBP < 130/DBP < 80 mmHg); combined hypertension (SBP ≥130/DBP ≥80 mmHg or on antihypertensive treatment); IDH (SBP <130/DBP >80 mmHg); isolated systolic hypertension (ISH: SBP ≥130/DBP <80 mmHg). The association between hypertension status and TOD was assessed by multivariable-adjusted logistic models.
RESULTS
RESULTS
Using normotension as reference, IDH was not significantly associated with NTproBNP levels (adjusted odds ratio [OR] 1.04 [95%CI 0.82;1.32], p = .750), microalbuminuria (OR 0.99 [0.69; 1.42], p = .960), diastolic dysfunction (OR 1.53 [0.88; 2.68], p = .130), left ventricular (LV) mass index (OR per 10 g/m
CONCLUSIONS
CONCLUSIONS
IDH was not significantly associated with TOD. Further studies are needed to clarify the clinical role of IDH. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01391442.
Identifiants
pubmed: 34523741
doi: 10.1002/clc.23713
pmc: PMC8571544
doi:
Banques de données
ClinicalTrials.gov
['NCT01391442']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1516-1525Subventions
Organisme : Fondation de Recherche en Hypertension Artérielle
Organisme : ERA-CVD EXPERT
ID : ANR-16-ECVD-0002-02
Organisme : FOCUS-MR
ID : ANR-15-CE14-0032-01
Organisme : CPER IT2MP
Organisme : FEDER Lorraine
Organisme : French PIA project
ID : ANR-15-IDEX-04-LUE
Organisme : FIGHT-HF
ID : ANR-15-RHU-0004
Organisme : French National Research Agency
Organisme : Contrat de Plan Etat-Lorraine and FEDER Lorraine
Organisme : French Ministry of Health
Informations de copyright
© 2021 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.
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