The Debate Between Two of the Founders of American Psychiatric Genetics, Aaron Rosanoff and Abraham Myerson, on Mendelian Models for Psychiatric Illness: 1911-1917.
Journal
The Journal of nervous and mental disease
ISSN: 1539-736X
Titre abrégé: J Nerv Ment Dis
Pays: United States
ID NLM: 0375402
Informations de publication
Date de publication:
01 Mar 2022
01 Mar 2022
Historique:
pubmed:
16
9
2021
medline:
3
5
2022
entrez:
15
9
2021
Statut:
ppublish
Résumé
In 1911, Aaron Rosanoff published among the first pedigree studies of psychiatric illness, and the first ever in the United States, claiming that the neuropathic constitution was transmitted in as a Mendelian recessive disorder. In 1917, Abraham Myerson harshly critiqued that study, focusing on the very wide phenotypic definition of neuropathic constitution. Here, I describe Rosanoff and Myerson's backgrounds, the details of Rosanoff's study, and Myerson's critique and put this controversy in the context of the history of psychiatric genetics, emphasizing four themes: a) the close interrelationship between psychiatric diagnosis and models of genetic transmission, b) the strong attraction of Mendelian models to psychiatric geneticists after their 1900 rediscovery, c) the controversy about whether familial transmission of psychiatric illness is largely homogeneous or heterogeneous, and d) the methods taken by researchers to the problems of psychiatric genetics that typically emerged as part of their broader approach to the nature of psychiatric illness.
Identifiants
pubmed: 34524228
doi: 10.1097/NMD.0000000000001419
pii: 00005053-202203000-00001
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-155Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Références
Baron M, Risch N, Hamburger R, Mandel B, Kushner S, Newman M, Drumer D, Belmaker RH (1987) Genetic linkage between X-chromosome markers and bipolar affective illness. Nature . 326:289–292.
Bleuler E (1911) Dementia praecox oder gruppe der schizophrenien. In Aschaffenburg G (Ed), Handbuch der psychiatrie: Spezieller teil 4 . Franz Deuticke: Leipzig und Wien.
Bleuler E (1917) Mendelismus bei psychosen, speziell bei schizophrenie. Schweizer Arch Neurol Psychiatr . 1:19–40.
Caspi A, Houts RM, Belsky DW, Goldman-Mellor SJ, Harrington H, Israel S, Meier MH, Ramrakha S, Shalev I, Poulton R, Moffitt TE (2014) The p factor: One general psychopathology factor in the structure of psychiatric disorders? Clin Psychol Sci . 2:119–137.
Craddock N, Owen MJ (2010) The Kraepelinian dichotomy—Going, going…but still not gone. Br J Psychiatry . 196:92–95.
Dahl L (1868) Über einige resultate der zählung der geisteskranken in Norwegen den 31 December 1865. Allg Zeitschr Psych Gerichtl Med . 25:839–846.
Davenport CB (1915a) The feebly inhibited: I. Violent temper and its inheritance. Proc Natl Acad Sci U S A . 1:37–38.
Davenport CB (1915b) The feebly inhibited: nomadism, or the wandering impulse with special reference to heredity, inheritance of temperament . Washington, DC: Carnegie Institution of Washington.
Dowbiggin I (1991) Inheriting madness: Professionalization and psychiatric knowledge in nineteenth-century France . Berkeley, CA: University of California Press.
Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, Hostetter AM, Housman DE (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature . 325:783–787.
Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, Sakaguchi AY, Young AB, Shoulson I, Bonilla E, Martin JB (1983) A polymorphic DNA marker genetically linked to Huntington's disease. Nature . 306:234–238.
Hoffmann H (1921) Studien über vererbung und entstehung geistiger störungen: II. Die nachkommenschaft bei endogenen psychosen. In Studien über vererbung und entstehung geistiger störungen (pp 4–231). Berlin: Springer.
Kendler KS (2020) Eugen Bleuler's views on the genetics of schizophrenia in 1917. Schizophr Bull . 46:758–764.
Kendler KS (2021) The prehistory of psychiatric genetics: 1780–1910. Am J Psychiatry . 178:490–508.
Kendler KS, Klee A (2020) The turn to controls and the refinement of the concept of hereditary burden: The 1895 study of Jenny Koller. Am J Med Genet B Neuropsychiatr Genet . 183:433–442.
Kendler KS, Klee A (2021a) Julius Wagner von Jauregg, Otto Diem and research methods for assessing the contributions of hereditary burden to mental illness risk: 1902–1906. Am J Med Genet B Neuropsychiatr Genet . 186:50–64.
Kendler KS, Klee A (2021b) Philipp Jolly and his 1913 “the heredity of psychosis”: Homogeneity versus heterogeneity of familial transmission and an early look at Mendelian models for manic-depressive illness and dementia praecox. Am J Med Genet B Neuropsychiatr Genet . 186:90–100.
Kevles DJ (1985) In the name of eugenics: Genetics and the uses of human heredity . Los Angeles, CA: University of California Press.
Kosters G, Steinberg H, Kirkby KC, Himmerich H (2015) Ernst Rudin's unpublished 1922–1925 study “inheritance of manic-depressive insanity”: Genetic research findings subordinated to eugenic ideology. PLoS Genet . 11:e1005524.
Kraepelin E (1903) Psychiatrie: Ein lehrbuch fur studirende und aerzte (7th ed, Vol 2). Leipzig: J. A. Barth, 1903–1904.
MacDowell EC (1946) Charles Benedict Davenport, 1866–1944: A study of conflicting influences. Bios . 2–50.
Mehler BA (1988) A history of the American Eugenics Society, 1921–1940 . Champaign, IL: University of Illinois at Urbana-Champaign.
Mott F (1914) A study of the neuropathic inheritance especially in relation to insanity. Arch Neurol Psychiatry (London) . 6:79–98.
Myerson A (1917) Psychiatric family studies. Am J Psychiatry . 73:355–486.
Myerson A (1918) Psychiatric family studies. Second paper: Dealing with the psychoses of brothers and sisters. Am J Psychiatry . 74:497–554.
Myerson A (1925) The inheritance of mental diseases . Baltimore, MD: Williams & Wilkins.
Pearson K (1900) X. On the criterion that a given system of deviations from the probable in the case of a correlated system of variables is such that it can be reasonably supposed to have arisen from random sampling. Lond Edinb Dubl Philos Mag J Sci . 50:157–175.
Porter TM (2018) Genetics in the madhouse: The unknown history of human heredity . Princeton, NJ: Princeton University Press.
Rosanoff A (1912) The inheritance of the neuropathic constitution. JAMA . 58:1266–1269.
Rosanoff AJ (1920) Manual of psychiatry . New York: Wiley.
Rosanoff AJ, Handy LM, Rosanoff Plesset I (1935) The etiology of manic-depressive sundromes with special reference to their occurance in twins. Am J Psychiatry . 91:725–762.
Rosanoff AJ, Orr FI (1911a) A study of heredity in insanity in the light of the Mendelian theory. Am J Insanity . 68:221–261.
Rosanoff AJ, Orr FI (1911b). A study of heredity of insanity in the light of the Mendelian theory . Eugenics Records Office, Bulletin #5: Cold Springs Harbor.
Rosenberg CE (1961) Charles Benedict Davenport and the beginning of human genetics. Bull Hist Med . 35:266–276.
Rudin E (1916) Studien uber vererbung und entstehung geistiger storungen. I. Zur vererbung und neuentstehung der dementia praecox (Studies on the inheritance and origin of mental illness. I. The problem of the inheritance and primary origin of dementia praecox). In Monographien aus dem gesamtgebiet der neurologie und psychiatrie, number 12 . Berlin: Springer.
Sherrington R, Brynjolfsson J, Petursson H, Potter M, Dudleston K, Barraclough B, Wasmuth J, Dobbs M, Gurling H (1988) Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature . 336:164–167.