Impact on the Risk and Severity of Childhood Onset Schizophrenia of Schizophrenia Risk Genetic Variants at the DRD2 and ZNF804A Loci.
Autism
Childhood-onset schizophrenia
Genes
Symptom severity
Journal
Child psychiatry and human development
ISSN: 1573-3327
Titre abrégé: Child Psychiatry Hum Dev
Pays: United States
ID NLM: 1275332
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
accepted:
07
09
2021
pubmed:
16
9
2021
medline:
25
1
2023
entrez:
15
9
2021
Statut:
ppublish
Résumé
The study explored whether schizophrenia risk alleles of the DRD2 rs2514218 and ZNF804A rs1344706 polymorphisms also influenced the risk and severity of childhood-onset schizophrenia (COS) and differentiated it from autism spectrum disorders (ASD). We compared 75 children with COS to 75 children with ASD, 150 patients with adult-onset schizophrenia and 150 healthy individuals. Frequency of the DRD2 T-allele, assumed to be protective against schizophrenia overall, was higher in COS compared to adult-onset schizophrenia and healthy controls. The risk allele A of ZNF804A was associated with greater severity of negative symptoms in COS. The latter result is consistent with the involvement of ZNF804A in the development of severe forms of schizophrenia. The findings regarding DRD2 suggest that the same genetic variants may play different roles in schizophrenia with childhood and adult onset. This warrants further research, since D2 receptor blockade is a general pharmacodynamic property of antipsychotics.
Identifiants
pubmed: 34524581
doi: 10.1007/s10578-021-01245-z
pii: 10.1007/s10578-021-01245-z
doi:
Substances chimiques
Kruppel-Like Transcription Factors
0
ZNF804A protein, human
0
DRD2 protein, human
0
Receptors, Dopamine D2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-247Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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