ADAR1 edits the SenZ and SenZ-ability of RNA.

Adenosine Deaminase / genetics Animals Autoimmune Diseases of the Nervous System Mice RNA / genetics RNA Editing RNA-Binding Proteins / genetics

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
14 09 2021
Historique:
entrez: 15 9 2021
pubmed: 16 9 2021
medline: 4 11 2021
Statut: ppublish

Résumé

Some RNAs can assume a Z conformation, an unusual, left-handed turn. In this issue of Immunity, three studies report that mutations in the Zα-RNA binding domain of the adenosine deaminase ADAR1 are sufficient to induce autoinflammatory disease in mice, which models human Aicardí-Goutières syndrome, highlighting the important role of Z-RNA editing in limiting innate immune recognition of endogenous RNA.

Identifiants

DOI: 10.1016/j.immuni.2021.08.021 PMID: 34525334
pubmed: 34525334
pii: S1074-7613(21)00355-1
doi: 10.1016/j.immuni.2021.08.021
pii:
doi:

Substances chimiques

RNA-Binding Proteins 0
RNA 63231-63-0
ADAR1 protein, mouse EC 3.5.4.4
Adenosine Deaminase EC 3.5.4.4

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

1909-1911

Commentaires et corrections

Type : CommentOn
Type : CommentOn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Thomas Zillinger (T)

Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.

Eva Bartok (E)

Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany; Unit of Experimental Immunology, Department of Biomedical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium. Electronic address: ebartok@uni-bonn.de.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Aminohydrolases › Nucleoside deaminases › Adenosine deaminase › ADAR1 edits the SenZ and SenZ-ability of RNA.
questionsmedicales.fr › Eucaryotes › Animaux › ADAR1 edits the SenZ and SenZ-ability of RNA.
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › ADAR1 edits the SenZ and SenZ-ability of RNA.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › ADAR1 edits the SenZ and SenZ-ability of RNA.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ADAR1 edits the SenZ and SenZ-ability of RNA.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Édition des ARN › ADAR1 edits the SenZ and SenZ-ability of RNA.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › ADAR1 edits the SenZ and SenZ-ability of RNA.