Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi-functional iron oxide nanoprobe.
Animals
Asialoglycoprotein Receptor
/ metabolism
Biocompatible Materials
Biomarkers
Cell Line, Tumor
Cell Survival
Chemical Phenomena
Chemistry Techniques, Synthetic
Ferric Compounds
/ chemistry
Glucans
/ chemistry
Liver Cirrhosis
/ diagnosis
Magnetic Resonance Imaging
/ methods
Magnetite Nanoparticles
/ chemistry
Male
Molecular Probes
/ chemical synthesis
Molecular Targeted Therapy
/ methods
Optical Imaging
/ methods
Rats
Reactive Oxygen Species
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
received:
20
02
2021
accepted:
24
08
2021
entrez:
16
9
2021
pubmed:
17
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Early diagnosis and therapy of liver fibrosis is of utmost importance, especially considering the increased incidence of alcoholic and non-alcoholic liver syndromes. In this work, a systematic study is reported to develop a dual function and biocompatible nanoprobe for liver specific diagnostic and therapeutic applications. A polysaccharide polymer, pullulan stabilized iron oxide nanoparticle (P-SPIONs) enabled high liver specificity via asialogycoprotein receptor mediation. Longitudinal and transverse magnetic relaxation rates of 2.15 and 146.91 mM
Identifiants
pubmed: 34526590
doi: 10.1038/s41598-021-97808-0
pii: 10.1038/s41598-021-97808-0
pmc: PMC8443657
doi:
Substances chimiques
Asialoglycoprotein Receptor
0
Biocompatible Materials
0
Biomarkers
0
Ferric Compounds
0
Glucans
0
Magnetite Nanoparticles
0
Molecular Probes
0
Reactive Oxygen Species
0
ferric oxide
1K09F3G675
pullulan
8ZQ0AYU1TT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18324Informations de copyright
© 2021. The Author(s).
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