When Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation.

BI-ALCL Kaposi's sarcoma Marjolin's ulcer chronic inflammation malignant degeneration radiation-induced sarcoma

Journal

Seminars in plastic surgery
ISSN: 1535-2188
Titre abrégé: Semin Plast Surg
Pays: United States
ID NLM: 101131275

Informations de publication

Date de publication:
Aug 2021
Historique:
entrez: 16 9 2021
pubmed: 17 9 2021
medline: 17 9 2021
Statut: ppublish

Résumé

Chronic inflammation, long implicated in the genesis of malignancy, is now understood to underlie an estimated 25% of all cancers. The most pertinent malignancies, to the plastic surgeon, associated with the degeneration of chronic inflammation include Marjolin's ulcer, breast implant-associated large cell lymphoma, radiation-induced sarcoma, and Kaposi's sarcoma. The cellular and genetic damage incurred by a prolonged inflammatory reaction is controlled by an increasingly understood cytokinetic system. Advances in understanding the chronic inflammatory cascade have yielded new therapeutics and therapeutic targets.

Identifiants

pubmed: 34526863
doi: 10.1055/s-0041-1731462
pii: 01307
pmc: PMC8432987
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

159-163

Informations de copyright

Thieme. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of Interest None declared.

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Auteurs

Christopher Conlon (C)

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Lauren Pupa (L)

School of Medicine, Baylor College of Medicine, Houston, Texas.

Edward M Reece (EM)

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.
Division of Plastic Surgery, Texas Children's Hospital, Houston, Texas.

Carrie K Chu (CK)

Department of Plastic Surgery, MD Anderson Cancer Center, University of Texas, Houston, Texas.

Jessie Z Yu (JZ)

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Joshua Vorstenbosch (J)

Division of Plastic Surgery, McGill University, Montreal, Canada.

Sebastian Winocour (S)

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Classifications MeSH