Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications.
VAC
negative pressure wound therapy
semiocclusive membrane
wounds
Journal
Seminars in plastic surgery
ISSN: 1535-2188
Titre abrégé: Semin Plast Surg
Pays: United States
ID NLM: 101131275
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
entrez:
16
9
2021
pubmed:
17
9
2021
medline:
17
9
2021
Statut:
ppublish
Résumé
Negative pressure wound therapy (NPWT) promotes healing by evenly applying negative pressure on the surface of the wound. The system consists of a sponge, a semiocclusive barrier, and a fluid collection system. Its effectiveness is explained by four main mechanisms of action, including macrodeformation of the tissues, drainage of extracellular inflammatory fluids, stabilization of the environment of the wound, and microdeformation. Rarely will complications linked to NPWT occur, but special care must be taken to prevent events such as toxic shock syndrome, fistulization, bleeding, and pain. New NPWT modalities have been recently developed to make NPWT suitable for a wider variety of wounds. These include NPWT with instillation therapy (NPWTi-d), different cleansing options, and application of NPWT on primarily closed incisions. Finally, vacuum-assisted wound closure therapy has been demonstrated to be efficient for various clinical settings, such as the management of diabetic foot ulcers, pressure ulcerations, chronic wounds, and skin grafts.
Identifiants
pubmed: 34526864
doi: 10.1055/s-0041-1731792
pii: 01315
pmc: PMC8432996
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
164-170Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of Interest None declared.
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