Efficacy of Δ

aging cannabidiol cognition endocannabinoid system Δ9-tetrahydrocannabinol

Journal

Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824

Informations de publication

Date de publication:
2021
Historique:
received: 01 06 2021
accepted: 06 08 2021
entrez: 16 9 2021
pubmed: 17 9 2021
medline: 17 9 2021
Statut: epublish

Résumé

Decline in cognitive performance, an aspect of the normal aging process, is influenced by the endocannabinoid system (ECS). Cannabinoid receptor 1 (CB1) signaling diminishes with advancing age in specific brain regions that regulate learning and memory and abolishing CB1 receptor signaling accelerates cognitive aging in mice. We recently demonstrated that prolonged exposure to low dose (3 mg/kg/day) Δ

Identifiants

pubmed: 34526890
doi: 10.3389/fnagi.2021.718850
pmc: PMC8435893
doi:

Types de publication

Journal Article

Langues

eng

Pagination

718850

Informations de copyright

Copyright © 2021 Nidadavolu, Bilkei-Gorzo, Krämer, Schürmann, Palmisano, Beins, Madea and Zimmer.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Prakash Nidadavolu (P)

Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany.

Andras Bilkei-Gorzo (A)

Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany.

Michael Krämer (M)

Institute of Forensic Medicine, Medical Faculty, University of Bonn, Bonn, Germany.

Britta Schürmann (B)

Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany.

Michela Palmisano (M)

Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany.

Eva C Beins (EC)

Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany.
Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.

Burkhard Madea (B)

Institute of Forensic Medicine, Medical Faculty, University of Bonn, Bonn, Germany.

Andreas Zimmer (A)

Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany.

Classifications MeSH