Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability.
Glycyrrhiza uralensis
Tripterygium wilfordii
celastrol
glycyrrhetinic acid
inflammation
natural products
obesity
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
05
2021
accepted:
04
08
2021
entrez:
16
9
2021
pubmed:
17
9
2021
medline:
17
9
2021
Statut:
epublish
Résumé
Obesity is characterized by an excessive body mass, but is also closely associated with metabolic syndrome. And, so far, only limited pharmacological treatments are available for obesity management. Celastrol, a pentacyclic triterpenoid from a traditional Chinese medicine (
Identifiants
pubmed: 34526895
doi: 10.3389/fphar.2021.705252
pii: 705252
pmc: PMC8435713
doi:
Types de publication
Journal Article
Langues
eng
Pagination
705252Informations de copyright
Copyright © 2021 Zhou, Yuan, Shi, Hu, Wang, Yang, Pan, Kong, Shikov, Duez, Jin, Li and Hu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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