Characteristics of T-cell receptor repertoire of stem cell-like memory CD4+ T cells.
CD4+ memory T cell
Complementarity determining region 3
Public clonotypes
Stem-cell like CD4+ memory T cell
T-cell receptor beta chain repertoire
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
04
2021
accepted:
26
07
2021
entrez:
16
9
2021
pubmed:
17
9
2021
medline:
17
9
2021
Statut:
epublish
Résumé
Stem cell-like memory T cells (Tscm) combine phenotypes of naïve and memory. However, it remains unclear how T cell receptor (TCR) characteristics contribute to heterogeneity in Tscm and other memory T cells. We compared the TCR-beta (TRB) repertoire characteristics of CD4+ Tscm with those of naïve and other CD4+ memory (Tm) in 16 human subjects. Compared with Tm, Tscm had an increased diversity across all stretches of TRB repertoire structure, a skewed gene usage, and a shorter length distribution of CDR3 region. These distinctions between Tscm and Tm were enlarged in top1000 abundant clonotypes. Furthermore, top1000 clonotypes in Tscm were more public than those in Tm and grouped in more clusters, implying more epitope types recognized by top1000 clonotypes in Tscm. Importantly, self-reactive clonotypes were public and enriched in Tscm rather than Tm, of type one diabetes patients. Therefore, this study highlights the unique features of Tscm different from those of other memory subsets and provides clues to understand the physiological and pathological functions of Tscm.
Identifiants
pubmed: 34527440
doi: 10.7717/peerj.11987
pii: 11987
pmc: PMC8401816
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e11987Informations de copyright
©2021 Wang et al.
Déclaration de conflit d'intérêts
Shiyu Wang, Longlong Wang, Yang Liu and Ya Liu are employed by BGI-Shenzhen.
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