Understanding the pathogenesis of infectious diseases by single-cell RNA sequencing.
bacteria
fungi
immune response
infectious diseases
parasites
single-cell RNA sequencing
viruses
Journal
Microbial cell (Graz, Austria)
ISSN: 2311-2638
Titre abrégé: Microb Cell
Pays: Austria
ID NLM: 101632887
Informations de publication
Date de publication:
06 Sep 2021
06 Sep 2021
Historique:
received:
19
02
2021
revised:
13
07
2021
accepted:
21
07
2021
entrez:
16
9
2021
pubmed:
17
9
2021
medline:
17
9
2021
Statut:
epublish
Résumé
Infections are highly orchestrated and dynamic processes, which involve both pathogen and host. Transcriptional profiling at the single-cell level enables the analysis of cell diversity, heterogeneity of the immune response, and detailed molecular mechanisms underlying infectious diseases caused by bacteria, viruses, fungi, and parasites. Herein, we highlight recent remarkable advances in single-cell RNA sequencing (scRNA-seq) technologies and their applications in the investigation of host-pathogen interactions, current challenges and potential prospects for disease treatment are discussed as well. We propose that with the aid of scRNA-seq, the mechanism of infectious diseases will be further revealed thus inspiring the development of novel interventions and therapies.
Identifiants
pubmed: 34527720
doi: 10.15698/mic2021.09.759
pii: MIC0271E110
pmc: PMC8404151
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
208-222Informations de copyright
Copyright: © 2021 Huang et al.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have declared no conflict of interest.
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