Intracranial Displacement Measurements Within Targeted Anatomical Regions of a Postmortem Human Surrogate Brain Subjected to Impact.
Brain trauma
Cadaver
Concussion
Impact
PMHS
Journal
Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
03
03
2021
accepted:
19
08
2021
pubmed:
17
9
2021
medline:
2
2
2022
entrez:
16
9
2021
Statut:
ppublish
Résumé
The dynamic response of the human brain subjected to impulsive loading conditions is of fundamental importance to the understanding of traumatic brain injuries. Due to the complexity of such measurements, the existing experimental datasets available to researchers are sparse. However, these measurements are used extensively in the validation of complex finite element models used in the design of protective equipment and the development of injury mitigation strategies. The primary objective of this study was to develop a comprehensive methodology to measure displacement in specific anatomical regions of the brain. A state-of-the-art high-speed cineradiography system was used to capture brain motion in post-mortem human surrogate specimens at a rate of 7500 fps. This paper describes the methodology used to capture these data and presents measurements from these tests. Two-dimensional displacement fields are presented and analyzed based on anatomical regions of the brain. These data demonstrated a multi-modal displacement response in several regions of the brain. The full response of the brain consisted of an elastic superposition of a series of bulk rotations of the brain about its centre of gravity. The displacement field could be linked directly to specific anatomical regions. The methods presented mark an improvement in temporal and spatial resolution of data collection, which has implications for our developing understanding of brain trauma.
Identifiants
pubmed: 34528151
doi: 10.1007/s10439-021-02857-1
pii: 10.1007/s10439-021-02857-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2836-2851Subventions
Organisme : Canada Foundation for Innovation
ID : 32933
Organisme : Ontario Ministry of Research and Innovation
ID : ER-18-14-063
Organisme : Natural Sciences and Engineering Research Council
ID : CPG-151967
Organisme : CIHR
ID : CPG-151967
Pays : Canada
Organisme : CIHR
ID : CPG-151967
Pays : Canada
Organisme : CIHR
ID : CPG-151967
Pays : Canada
Informations de copyright
© 2021. Biomedical Engineering Society.
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