Activation of nucleus accumbens μ-opioid receptors enhances the response to a glycaemic challenge.

DAMGO glucose metabolism insulin tolerance test nucleus accumbens μ-opioid receptor

Journal

Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461

Informations de publication

Date de publication:
26 Aug 2021
Historique:
revised: 10 08 2021
received: 18 06 2021
accepted: 20 08 2021
pubmed: 17 9 2021
medline: 17 9 2021
entrez: 16 9 2021
Statut: aheadofprint

Résumé

Opioids are known to affect blood glucose levels but their exact role in the physiological control of glucose metabolism remains unclear. Although there are numerous studies investigating the peripheral effects of opioid stimulation, little is known about how central opioids control blood glucose and which brain areas are involved. One brain area possibly involved is the nucleus accumbens because, as well as being a key site for opioid effects on food intake, it has also been implicated in the control of blood glucose levels. Within the nucleus accumbens, μ-opioid receptors are most abundantly expressed. Therefore, in the present study, we investigated the role of μ-opioid receptors in the nucleus accumbens in the control of glucose metabolism. We show that infusion of the μ-opioid receptor agonist [d-Ala

Identifiants

DOI: 10.1111/jne.13036 PMID: 34528311 PMC: PMC9286654
pubmed: 34528311
doi: 10.1111/jne.13036
pmc: PMC9286654
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13036

Subventions

Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : NWO-VICI grant 016.160.617

Informations de copyright

© 2021 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.

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Auteurs

Laura L Koekkoek (LL)

Amsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Metabolism and Reward Group, An Institute of the Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

Tess Kool (T)

Amsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Metabolism and Reward Group, An Institute of the Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

Leslie Eggels (L)

Amsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Metabolism and Reward Group, An Institute of the Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

Luna L van der Gun (LL)

Amsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Metabolism and Reward Group, An Institute of the Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

Khalid Lamuadni (K)

Amsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Metabolism and Reward Group, An Institute of the Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

Margo Slomp (M)

Amsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Metabolism and Reward Group, An Institute of the Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

Charlene Diepenbroek (C)

Amsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Metabolism and Reward Group, An Institute of the Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

Mireillle J Serlie (MJ)

Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.

Andries Kalsbeek (A)

Amsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Hypothalamic Integration Mechanisms, An Institute of the Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.

Susanne E la Fleur (SE)

Amsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Metabolism and Reward Group, An Institute of the Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
ORCID: 0000-0002-4298-7451

Classifications MeSH