Blastic plasmacytoid dendritic-cell neoplasia: a challenging case report.
Aged
Antigens, CD
/ metabolism
Biomarkers, Tumor
/ genetics
Blast Crisis
/ drug therapy
Dendritic Cells
/ drug effects
Diagnosis, Differential
Diagnostic Errors
/ prevention & control
Hematologic Neoplasms
/ diagnosis
Humans
Male
Mutation
Prognosis
Recombinant Fusion Proteins
/ therapeutic use
Skin Neoplasms
/ diagnosis
AML
Blastic plasmacytoid dendritic cell-neoplasms (BPDCN)
MDS
Myeloid neoplasia
Tagraxofusp
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
13
06
2021
accepted:
23
08
2021
pubmed:
17
9
2021
medline:
8
3
2022
entrez:
16
9
2021
Statut:
ppublish
Résumé
Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an extremely rare disease that originates from dendritic cells and is associated with a poor overall survival (OS). Diagnostic and therapeutic standards are less well-established in comparison to other leukemic conditions and standards of care are lacking. Morphologic and molecular similarities to acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) are hard to distinguish. We here report a BPDCN patient with a long, challenging diagnostic period. While bone marrow biopsies initially failed to prove the correct diagnosis, a cutaneous biopsy finally identified a CD45
Identifiants
pubmed: 34529129
doi: 10.1007/s00432-021-03777-2
pii: 10.1007/s00432-021-03777-2
pmc: PMC8881430
doi:
Substances chimiques
Antigens, CD
0
Biomarkers, Tumor
0
Recombinant Fusion Proteins
0
tagraxofusp
8ZHS5657EH
Types de publication
Case Reports
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
743-748Informations de copyright
© 2021. The Author(s).
Références
Cancer Control. 2014 Oct;21(4):279-89
pubmed: 25310209
Leukemia. 2014 Apr;28(4):823-9
pubmed: 24072100
Haematologica. 2004 Jan;89(1):58-69
pubmed: 14754607
J Clin Exp Hematop. 2018 Mar 16;58(1):1-9
pubmed: 29415975
Biol Blood Marrow Transplant. 2016 Aug;22(8):1357-1367
pubmed: 27026248
Blood Adv. 2019 Dec 23;3(24):4238-4251
pubmed: 31869411
Adv Anat Pathol. 2009 Nov;16(6):392-404
pubmed: 19851130
Cancer Discov. 2017 Feb;7(2):156-164
pubmed: 27986708
Blood. 2009 Jul 30;114(5):937-51
pubmed: 19357394
Blood Adv. 2020 Aug 25;4(16):4020-4027
pubmed: 32841341
Am J Hematol. 2013 Dec;88(12):1055-61
pubmed: 23940084
Haematologica. 2013 Feb;98(2):239-46
pubmed: 23065521
Expert Rev Hematol. 2010 Oct;3(5):593-602
pubmed: 21083476