Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata.
3,5-Dimethylcoumarins
3-Methylcoumarin
Chelonopsis
Enzyme inhibition
Journal
Natural products and bioprospecting
ISSN: 2192-2195
Titre abrégé: Nat Prod Bioprospect
Pays: Germany
ID NLM: 101577734
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
06
08
2021
accepted:
12
09
2021
pubmed:
17
9
2021
medline:
17
9
2021
entrez:
16
9
2021
Statut:
ppublish
Résumé
Ten 3,5-dimethylcoumarins (1-6 and 8‒11) involving six new ones (1-6), together with a known 3-methylcoumarin (7), were isolated from the aerial parts of three Chelonopsis plants, C. praecox, C. odontochila, and C. pseudobracteata. The structures of the new compounds were determined by extensive HRESIMS, 1D and 2D NMR spectroscopic analyses. According to the substitution at C-5, these coumarins were classified into 5-methyl, 5-hydroxymethyl, 5-formyl, and 5-nor types. All the isolates were assayed for their inhibition on α-glucosidase, protein tyrosine phosphatase 1B, and T-cell protein tyrosine phosphatase in vitro.
Identifiants
pubmed: 34529253
doi: 10.1007/s13659-021-00318-9
pii: 10.1007/s13659-021-00318-9
pmc: PMC8599598
doi:
Types de publication
Journal Article
Langues
eng
Pagination
643-649Subventions
Organisme : Yunnan Provincial Department of Finance
ID : YNWR-QNBJ-2018-061
Organisme : Natural Science Foundation of Yunnan Province
ID : 2019FI017
Informations de copyright
© 2021. The Author(s).
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