Reproductive suppression of giraffe (Giraffa camelopardalis) under managed care using a GnRH immunological product.
estrone glucuronide
fecal hormones
immunocontraception
ovarian suppression
pregnanediol glucuronide
reversal
testosterone
Journal
Zoo biology
ISSN: 1098-2361
Titre abrégé: Zoo Biol
Pays: United States
ID NLM: 8807837
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
revised:
23
07
2021
received:
18
08
2020
accepted:
05
08
2021
pubmed:
17
9
2021
medline:
8
2
2022
entrez:
16
9
2021
Statut:
ppublish
Résumé
Giraffe present unique contraception challenges as males persistently pursue females during estrus. Year-round pursuit during frequent recurring estrus can pose significant risk under slippery conditions. Complete ovarian suppression is a useful tool in giraffe because it eliminates estrous behavior, interest from the male, and controls reproduction. Effective reproduction control in giraffes has been achieved with porcine zona pellucida, oral melengestrol acetate, and depot medroxy-progesterone acetate. However, these methods allow some degree of folliculogenesis and estrous behavior. Improvest® is a gonadotropin releasing hormone (GnRH) immunological product that elicits antibodies against GnRH and abrogates the effects of endogenous GnRH. This study evaluated the efficacy of Improvest® for gonadal suppression in seven females and one male giraffe by monitoring steroid hormones. Seven female giraffe were treated intramuscularly with an initial dose, a booster at 4 weeks and maintenance boosters at 3-month intervals (600 µg/dose) for 12 months. Six females were on supplemental contraception during the induction phase because separation from males was not possible. In the male (treated with 400 µg), testosterone concentrations decreased after the second injection. However, even with low serum testosterone concentrations, mounting (of nontreated females) behavior was still observed occasionally. Ovarian activity was suppressed in all treated females and interest by the males stopped; supplemental contraceptives (during the induction phase) did not impede the effect of Improvest®. After 15.3 months (seven doses), Improvest® was discontinued in three females which no longer needed contraception. In these females, ovarian activity was noted approximately 90 days after the last dose.
Substances chimiques
Gonadotropin-Releasing Hormone
33515-09-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
65-73Subventions
Organisme : Denver Zoo, Utah's Hogle Zoo, Birmingham Zoo, Sacramento Zoo, The Living Desert Zoo & Gardens, Southeastern Zoo Alliance for Reproduction and Conservation, and Zoetis
Informations de copyright
© 2021 Wiley Periodicals LLC.
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