Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates.
2019-nCoV Vaccine mRNA-1273
Animals
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
Antibody Affinity
Bronchoalveolar Lavage Fluid
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
COVID-19
/ immunology
COVID-19 Vaccines
/ administration & dosage
Female
Immunization Schedule
Immunization, Passive
Immunization, Secondary
Immunogenicity, Vaccine
Immunoglobulin G
/ immunology
Immunologic Memory
Lung
/ immunology
Macaca mulatta
Male
Mesocricetus
Nasal Mucosa
/ immunology
SARS-CoV-2
/ immunology
Spike Glycoprotein, Coronavirus
/ immunology
Vaccination
Vaccine Potency
Virus Replication
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
17 Sep 2021
17 Sep 2021
Historique:
entrez:
16
9
2021
pubmed:
17
9
2021
medline:
25
9
2021
Statut:
ppublish
Résumé
Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy. Here, nonhuman primates (NHPs) received either no vaccine or doses ranging from 0.3 to 100 μg of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. mRNA-1273 vaccination elicited circulating and mucosal antibody responses in a dose-dependent manner. Viral replication was significantly reduced in bronchoalveolar lavages and nasal swabs after SARS-CoV-2 challenge in vaccinated animals and most strongly correlated with levels of anti–S antibody and neutralizing activity. Lower antibody levels were needed for reduction of viral replication in the lower airway than in the upper airway. Passive transfer of mRNA-1273–induced immunoglobulin G to naïve hamsters was sufficient to mediate protection. Thus, mRNA-1273 vaccine–induced humoral immune responses are a mechanistic correlate of protection against SARS-CoV-2 in NHPs.
Identifiants
pubmed: 34529476
doi: 10.1126/science.abj0299
pmc: PMC8449013
mid: NIHMS1734565
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Immunoglobulin G
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
2019-nCoV Vaccine mRNA-1273
EPK39PL4R4
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabj0299Subventions
Organisme : Intramural NIH HHS
ID : ZIA AI005150
Pays : United States
Commentaires et corrections
Type : UpdateOf
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