Trends in the prevalence of microscopically-confirmed schistosomiasis in the South African public health sector, 2011-2018.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
04
02
2021
accepted:
20
07
2021
entrez:
16
9
2021
pubmed:
17
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Schistosomiasis, also known as bilharzia, is a chronic parasitic blood fluke infection acquired through contact with contaminated surface water. The illness may be mild or can cause significant morbidity with potentially serious complications. Children and those living in rural areas with limited access to piped water and services for healthcare are the most commonly infected. To address the prevalence of the disease in parts of South Africa (SA) effective national control measures are planned, but have not yet been implemented. This study aimed to estimate the prevalence and trends of public sector laboratory-confirmed schistosomiasis cases in SA over an eight-year (2011-2018) period, to inform future control measures. This is a descriptive analysis of secondary data from the National Health Laboratory Service (NHLS). The study included all records of patients for whom microscopic examination detected Schistosoma species eggs in urine or stool specimens from January 2011 to December 2018. Crude estimates of the prevalence were calculated using national census mid-year provincial population estimates as denominators, and simple linear regression was used to analyse prevalence trends. A test rate ratio was developed to describe variations in testing volumes among different groups and to adjust prevalence estimates for testing variations. A total number of 135 627 schistosomiasis cases was analysed with the highest prevalence observed among males and individuals aged 5-19 years. We describe ongoing endemicity in the Eastern Cape Province, and indicate important differences in the testing between population groups. While there was no overall change in the prevalence of schistosomiasis during the analysis period, an average of 36 people per 100 000 was infected annually. As such, this represents an opportunity to control the disease and improve quality of life of affected people. Laboratory-based surveillance is a useful method for reporting occurrence and evaluating future intervention programs where resources to implement active surveillance are limited.
Sections du résumé
BACKGROUND
Schistosomiasis, also known as bilharzia, is a chronic parasitic blood fluke infection acquired through contact with contaminated surface water. The illness may be mild or can cause significant morbidity with potentially serious complications. Children and those living in rural areas with limited access to piped water and services for healthcare are the most commonly infected. To address the prevalence of the disease in parts of South Africa (SA) effective national control measures are planned, but have not yet been implemented. This study aimed to estimate the prevalence and trends of public sector laboratory-confirmed schistosomiasis cases in SA over an eight-year (2011-2018) period, to inform future control measures.
METHODOLOGY & PRINCIPAL FINDINGS
This is a descriptive analysis of secondary data from the National Health Laboratory Service (NHLS). The study included all records of patients for whom microscopic examination detected Schistosoma species eggs in urine or stool specimens from January 2011 to December 2018. Crude estimates of the prevalence were calculated using national census mid-year provincial population estimates as denominators, and simple linear regression was used to analyse prevalence trends. A test rate ratio was developed to describe variations in testing volumes among different groups and to adjust prevalence estimates for testing variations. A total number of 135 627 schistosomiasis cases was analysed with the highest prevalence observed among males and individuals aged 5-19 years. We describe ongoing endemicity in the Eastern Cape Province, and indicate important differences in the testing between population groups.
CONCLUSION
While there was no overall change in the prevalence of schistosomiasis during the analysis period, an average of 36 people per 100 000 was infected annually. As such, this represents an opportunity to control the disease and improve quality of life of affected people. Laboratory-based surveillance is a useful method for reporting occurrence and evaluating future intervention programs where resources to implement active surveillance are limited.
Identifiants
pubmed: 34529659
doi: 10.1371/journal.pntd.0009669
pii: PNTD-D-21-00163
pmc: PMC8445405
doi:
Substances chimiques
Anthelmintics
0
Praziquantel
6490C9U457
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0009669Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Trends Parasitol. 2012 Feb;28(2):58-65
pubmed: 22245065
Clin Infect Dis. 2018 Jun 1;66(suppl_4):S245-S252
pubmed: 29860290
Acta Trop. 2003 May;86(2-3):125-39
pubmed: 12745133
Am J Trop Med Hyg. 1981 Mar;30(2):364-72
pubmed: 6972175
Lancet. 2014 Jun 28;383(9936):2253-64
pubmed: 24698483
Infect Dis Poverty. 2019 Jun 16;8(1):47
pubmed: 31202273
Pan Afr Med J. 2013 Dec 05;16:130
pubmed: 24839538
Biomed Res Int. 2016;2016:9162631
pubmed: 27631011
BMC Infect Dis. 2004 Oct 07;4:40
pubmed: 15471549
Int J Environ Res Public Health. 2018 Aug 31;15(9):
pubmed: 30200277
Infect Dis Poverty. 2017 Apr 7;6(1):83
pubmed: 28385154
PLoS Negl Trop Dis. 2011 Dec;5(12):e1396
pubmed: 22163056
PLoS Negl Trop Dis. 2009 Aug 25;3(8):e412
pubmed: 19707588
Chronic Illn. 2008 Mar;4(1):65-79
pubmed: 18322031
J Health Popul Nutr. 2009 Dec;27(6):739-45
pubmed: 20099757
Lancet. 2018 Nov 10;392(10159):1736-1788
pubmed: 30496103
Ann Trop Paediatr. 2001 Mar;21(1):50-8
pubmed: 11284248
PLoS Negl Trop Dis. 2009;3(2):e332
pubmed: 19238216
Infect Dis Poverty. 2017 May 1;6(1):57
pubmed: 28457230
Infect Dis Poverty. 2018 Jul 5;7(1):73
pubmed: 29986763
Parasitology. 2009 Nov;136(13):1859-74
pubmed: 19906318
PLoS One. 2020 Jun 4;15(6):e0232867
pubmed: 32497049
Infect Dis Poverty. 2017 Apr 7;6(1):85
pubmed: 28388940
Ann Trop Med Parasitol. 2003 Sep;97(6):617-27
pubmed: 14511560
Infect Dis Poverty. 2017 Nov 20;6(1):158
pubmed: 29151362
Parasitology. 2009 Nov;136(13):1719-30
pubmed: 19631008
Int J Infect Dis. 2017 Jan;54:130-137
pubmed: 27939558
PLoS Negl Trop Dis. 2020 Jun 15;14(6):e0008383
pubmed: 32542045