Thermal degradation of metabolites in urine using multiple isotope-labelled internal standards for off-line GC metabolomics - effects of injector and oven temperatures.
Derivatization
GC-QToF MS
Internal standards
Metabolomics
Temperature ramping
Thermal degradation
Journal
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
ISSN: 1873-376X
Titre abrégé: J Chromatogr B Analyt Technol Biomed Life Sci
Pays: Netherlands
ID NLM: 101139554
Informations de publication
Date de publication:
01 Sep 2021
01 Sep 2021
Historique:
received:
29
01
2021
revised:
29
06
2021
accepted:
16
08
2021
pubmed:
17
9
2021
medline:
27
1
2022
entrez:
16
9
2021
Statut:
ppublish
Résumé
Thermal processes are widely used in small molecule chemical analysis and metabolomics for derivatization, vaporization, chromatography, and ionization, especially in gas chromatography mass spectrometry (GC/MS). An optimized derivatization protocol has been successfully applied using multiple isotope labelled analytical internal standards of selected deuterated and
Identifiants
pubmed: 34530307
pii: S1570-0232(21)00383-4
doi: 10.1016/j.jchromb.2021.122902
pii:
doi:
Substances chimiques
Amino Acids
0
Fatty Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
122902Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.