NAD
Animals
Cell Line, Transformed
Cerebrovascular Circulation
/ drug effects
Cognitive Dysfunction
/ drug therapy
Male
Mice
Mitochondria
/ drug effects
NAD
/ pharmacology
Neuroinflammatory Diseases
/ drug therapy
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ metabolism
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species
/ antagonists & inhibitors
Sirtuin 1
/ metabolism
Chronic cerebral hypoperfusion
Microglia
Mitochondria
NAD+
ROS
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
16 Sep 2021
16 Sep 2021
Historique:
received:
14
06
2021
accepted:
24
08
2021
entrez:
17
9
2021
pubmed:
18
9
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. Nicotinamide adenine dinucleotide (NAD The bilateral common carotid artery occlusion (BCCAO) was performed to establish CCH models in Sprague-Dawley rats. The rats were given daily intraperitoneal injection of NAD NAD NAD
Sections du résumé
BACKGROUND
BACKGROUND
Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. Nicotinamide adenine dinucleotide (NAD
METHODS
METHODS
The bilateral common carotid artery occlusion (BCCAO) was performed to establish CCH models in Sprague-Dawley rats. The rats were given daily intraperitoneal injection of NAD
RESULTS
RESULTS
NAD
CONCLUSIONS
CONCLUSIONS
NAD
Identifiants
pubmed: 34530866
doi: 10.1186/s12974-021-02250-8
pii: 10.1186/s12974-021-02250-8
pmc: PMC8444613
doi:
Substances chimiques
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Ppargc1a protein, rat
0
Reactive Oxygen Species
0
NAD
0U46U6E8UK
Sirt1 protein, rat
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
207Subventions
Organisme : national natural science foundation of china
ID : 81871103
Organisme : national natural science foundation of china
ID : 81870952
Organisme : national natural science foundation of china
ID : 81974158
Informations de copyright
© 2021. The Author(s).
Références
Nature. 2010 Apr 29;464(7293):1313-9
pubmed: 20357764
Antioxid Redox Signal. 2009 Oct;11(10):2505-16
pubmed: 19331546
Exp Neurol. 2015 Oct;272:97-108
pubmed: 25987538
J Neurosci. 2010 Jul 21;30(29):9695-707
pubmed: 20660252
Neurobiol Aging. 2013 Jun;34(6):1581-8
pubmed: 23312803
J Am Heart Assoc. 2016 Jun 13;5(6):
pubmed: 27412896
Glia. 2018 Jan;66(1):34-46
pubmed: 28722234
Cardiovasc Diabetol. 2018 Aug 2;17(1):111
pubmed: 30071860
EMBO Rep. 2020 Apr 3;21(4):e49799
pubmed: 32202065
J Neuroinflammation. 2017 Apr 11;14(1):81
pubmed: 28399892
Mol Cells. 2016 Feb;39(2):87-95
pubmed: 26831453
Exp Neurol. 2020 Mar;325:113144
pubmed: 31837320
Stroke. 2004 Nov;35(11):2598-603
pubmed: 15472111
Biol Rev Camb Philos Soc. 2017 Nov;92(4):2046-2069
pubmed: 28220655
Lancet. 2015 Oct 24;386(10004):1698-706
pubmed: 26595643
Redox Biol. 2019 Jan;20:247-260
pubmed: 30384259
Lasers Med Sci. 2009 Jul;24(4):639-51
pubmed: 19050826
Nature. 2012 Jan 11;481(7382):463-8
pubmed: 22237023
Prog Retin Eye Res. 2020 Nov;79:100858
pubmed: 32298788
JCI Insight. 2020 Aug 6;5(15):
pubmed: 32759500
J Neuroinflammation. 2020 Jan 3;17(1):2
pubmed: 31900229
Int J Mol Sci. 2020 May 13;21(10):
pubmed: 32414136
Immunology. 2014 Jun;142(2):151-66
pubmed: 24329535
Neurochem Int. 2019 Oct;129:104469
pubmed: 31100304
J Clin Invest. 2020 Nov 2;130(11):6054-6063
pubmed: 32790648
Nat Neurosci. 2019 Mar;22(3):401-412
pubmed: 30742114
Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2802-11
pubmed: 25596427
Science. 1999 Mar 5;283(5407):1482-8
pubmed: 10066162
Nat Neurosci. 2018 Oct;21(10):1359-1369
pubmed: 30258234
Semin Cell Dev Biol. 2020 Mar;99:163-171
pubmed: 31154011
Clin Sci (Lond). 2017 Sep 28;131(19):2451-2468
pubmed: 28963120
J Biomed Opt. 2010 Jan-Feb;15(1):011109
pubmed: 20210435
J Neuroinflammation. 2019 Dec 9;16(1):260
pubmed: 31815636
Antioxid Redox Signal. 2014 Oct 20;21(12):1766-801
pubmed: 24597893
Nat Rev Neurosci. 2007 Jan;8(1):57-69
pubmed: 17180163
Physiol Rev. 2014 Jul;94(3):909-50
pubmed: 24987008
Nutr Neurosci. 2020 Dec;23(12):955-970
pubmed: 30794076
Theranostics. 2021 Jan 1;11(4):1845-1863
pubmed: 33408785
Autophagy. 2020 Feb;16(2):289-312
pubmed: 30990365
Neurosci Biobehav Rev. 2018 May;88:187-200
pubmed: 29545166
Circ Res. 2015 May 22;116(11):1820-34
pubmed: 25999422
Front Aging Neurosci. 2020 Aug 20;12:252
pubmed: 32973488
Biochim Biophys Acta Mol Basis Dis. 2020 Oct 1;1866(10):165845
pubmed: 32473386
Cell. 2014 May 8;157(4):882-896
pubmed: 24813611
Mol Neurobiol. 2017 Jul;54(5):3670-3682
pubmed: 27206432
Free Radic Biol Med. 2014 Nov;76:34-46
pubmed: 25091898
Cell. 2013 Jul 18;154(2):430-41
pubmed: 23870130
Int J Mol Sci. 2019 Dec 07;20(24):
pubmed: 31817864
Antioxidants (Basel). 2020 Aug 13;9(8):
pubmed: 32823544
Nat Rev Neurol. 2021 Mar;17(3):157-172
pubmed: 33318676
Nat Med. 2011 Aug 21;17(9):1076-85
pubmed: 21857651
Nat Rev Nephrol. 2017 Oct;13(10):629-646
pubmed: 28804120
Redox Biol. 2015 Dec;6:472-485
pubmed: 26432659
Inflammation. 2020 Oct;43(5):1589-1598
pubmed: 32410071
Neuron. 2014 Feb 5;81(3):471-83
pubmed: 24507186
Cell Metab. 2019 Oct 1;30(4):630-655
pubmed: 31577933
Methods. 2014 Jun 1;67(3):354-63
pubmed: 24561167
Nucleic Acids Res. 2008 Jan;36(Database issue):D480-4
pubmed: 18077471
Autophagy. 2019 Jun;15(6):1112-1114
pubmed: 30922179
Science. 2015 Dec 4;350(6265):1208-13
pubmed: 26785480
Alzheimers Dement. 2016 Jun;12(6):719-32
pubmed: 27179961
Cell Metab. 2016 Oct 11;24(4):566-581
pubmed: 27732836
Glia. 2019 Jun;67(6):1017-1035
pubmed: 30548343
Antioxid Redox Signal. 2014 Mar 1;20(7):1126-67
pubmed: 23991888
Immunol Rev. 2016 Sep;273(1):180-93
pubmed: 27558335
Basic Res Cardiol. 2020 Aug 10;115(5):57
pubmed: 32778948
Oxid Med Cell Longev. 2020 Jan 4;2020:4717258
pubmed: 31998437
Curr Alzheimer Res. 2017;14(11):1140-1148
pubmed: 28164764
Nat Rev Nephrol. 2020 Feb;16(2):99-111
pubmed: 31673160
Cell. 2019 Oct 3;179(2):292-311
pubmed: 31585077