Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer.

Animals Apoptosis / genetics Cell Cycle Proteins / genetics Cell Line, Tumor Child Gene Expression Profiling Gene Expression Regulation, Neoplastic HEK293 Cells Humans Kaplan-Meier Estimate Mice, Inbred NOD Mice, Knockout Mice, SCID Oncogene Proteins, Fusion / genetics Protein Serine-Threonine Kinases / genetics Proto-Oncogene Proteins / genetics RNA Interference RNAi Therapeutics / methods Sarcoma, Ewing / genetics Signal Transduction / genetics Xenograft Model Antitumor Assays / methods Polo-Like Kinase 1

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
16 09 2021
Historique:
received: 03 12 2020
accepted: 17 08 2021
entrez: 17 9 2021
pubmed: 18 9 2021
medline: 21 10 2021
Statut: epublish

Résumé

Chromosomal instability (CIN) is a hallmark of cancer

Identifiants

DOI: 10.1038/s41467-021-25553-z PMID: 34531368 PMC: PMC8445938
pubmed: 34531368
doi: 10.1038/s41467-021-25553-z
pii: 10.1038/s41467-021-25553-z
pmc: PMC8445938
doi:

Substances chimiques

Cell Cycle Proteins 0
EWSR1-FLI1 fusion protein, human 0
Oncogene Proteins, Fusion 0
PRC1 protein, human 0
Proto-Oncogene Proteins 0
Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5356

Informations de copyright

© 2021. The Author(s).

Références

Nat Commun. 2019 Sep 11;10(1):4128
pubmed: 31511524
Nature. 2020 Sep;585(7825):440-446
pubmed: 32908304
Cell. 2012 Jun 8;149(6):1233-44
pubmed: 22682246
Oncoimmunology. 2018 Jul 23;7(9):e1481558
pubmed: 30228952
Methods Mol Biol. 2021;2226:159-166
pubmed: 33326100
Mol Biol Cell. 2019 Jan 1;30(1):42-55
pubmed: 30379607
Nat Rev Clin Oncol. 2018 Mar;15(3):139-150
pubmed: 29297505
Cell Death Dis. 2019 Feb 11;10(2):116
pubmed: 30741933
PLoS Biol. 2005 Mar;3(3):e69
pubmed: 15737063
EBioMedicine. 2019 Sep;47:156-162
pubmed: 31427232
Cell Cycle. 2019 Nov;18(21):2828-2848
pubmed: 31516082
Am J Cancer Res. 2015 Dec 15;6(1):97-104
pubmed: 27073727
Cancers (Basel). 2020 Mar 10;12(3):
pubmed: 32164354
Int J Cancer. 2016 Jan 15;138(2):497-506
pubmed: 26260582
Bio Protoc. 2018 Sep 5;8(17):
pubmed: 30263905
Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10149-54
pubmed: 18626011
Cancer Cell. 2014 Nov 10;26(5):668-681
pubmed: 25453903
Nat Rev Mol Cell Biol. 2010 Mar;11(3):220-8
pubmed: 20177397
Nature. 2020 Apr;580(7803):396-401
pubmed: 32296180
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Cell. 2018 Sep 6;174(6):1347-1360
pubmed: 30193109
Methods Mol Biol. 2021;2226:303-333
pubmed: 33326111
Nat Genet. 2015 Sep;47(9):1073-8
pubmed: 26214589
Nat Rev Genet. 2012 Jan 24;13(3):189-203
pubmed: 22269907
Development. 2014 Jan;141(1):219-23
pubmed: 24346702
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Nature. 2012 Sep 6;489(7414):57-74
pubmed: 22955616
Nat Cell Biol. 2007 Apr;9(4):436-44
pubmed: 17351640
Mol Biol Cell. 2012 Jul;23(14):2702-11
pubmed: 22621898
Clin Cancer Res. 2007 Apr 15;13(8):2429-40
pubmed: 17438102
Trends Cancer. 2018 Jan;4(1):59-73
pubmed: 29413422
Nat Rev Dis Primers. 2018 Jul 5;4(1):5
pubmed: 29977059
Methods Mol Biol. 2018;1711:351-398
pubmed: 29344898
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Mol Biol Cell. 2012 Mar;23(6):1024-34
pubmed: 22278743
PLoS Genet. 2014 Jul 10;10(7):e1004475
pubmed: 25010205
Nature. 2018 Mar 15;555(7696):321-327
pubmed: 29489754
Cell Cycle. 2009 Feb 1;8(3):498-504
pubmed: 19177017
Lancet Oncol. 2010 Feb;11(2):174-83
pubmed: 20152769
Science. 2012 Aug 17;337(6096):816-21
pubmed: 22745249
Science. 2013 Feb 15;339(6121):823-6
pubmed: 23287722
Nat Commun. 2020 May 15;11(1):2423
pubmed: 32415069
Cancer Discov. 2014 Nov;4(11):1326-41
pubmed: 25186949
Nat Protoc. 2007;2(7):1722-33
pubmed: 17641637
Cancer Discov. 2014 Nov;4(11):1342-53
pubmed: 25223734
Oncotarget. 2017 Aug 4;9(2):1587-1601
pubmed: 29416716
Pediatr Blood Cancer. 2014 Jan;61(1):158-64
pubmed: 23956067
Nature. 2020 Sep;585(7825):447-452
pubmed: 32908313
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):E4134-41
pubmed: 24133140

Auteurs

Jing Li (J)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.

Shunya Ohmura (S)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.

Aruna Marchetto (A)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.

Martin F Orth (MF)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.

Roland Imle (R)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Soft tissue sarcoma Junior Research Group, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
ORCID: 0000-0001-9564-6952

Marlene Dallmayer (M)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Department of General Pediatrics, University Hospital Münster, Münster, Germany.

Julian Musa (J)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Maximilian M L Knott (MML)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
ORCID: 0000-0002-6995-3702

Tilman L B Hölting (TLB)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
ORCID: 0000-0001-5598-7330

Stefanie Stein (S)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.

Cornelius M Funk (CM)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
ORCID: 0000-0002-0837-3237

Ana Sastre (A)

Unidad Hemato-oncología Pediátrica, Hospital Infantil Universitario La Paz, Madrid, Spain.

Javier Alonso (J)

Pediatric Solid Tumour Laboratory, Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III (CB06/07/1009; CIBERER-ISCIII), Madrid, Spain.
ORCID: 0000-0002-6287-8391

Felix Bestvater (F)

Light Microscopy Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Merve Kasan (M)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.

Laura Romero-Pérez (L)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
ORCID: 0000-0003-3196-4382

Wolfgang Hartmann (W)

Division of Translational Pathology, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Münster, Germany.
ORCID: 0000-0002-7609-5021

Andreas Ranft (A)

Pediatrics III, AYA Unit, West German Cancer Centre, University Hospital Essen, Essen, Germany.
German Cancer Consortium (DKTK), partner site Essen, Essen, Germany.

Ana Banito (A)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Soft tissue sarcoma Junior Research Group, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.

Uta Dirksen (U)

Pediatrics III, AYA Unit, West German Cancer Centre, University Hospital Essen, Essen, Germany.
German Cancer Consortium (DKTK), partner site Essen, Essen, Germany.
ORCID: 0000-0002-5435-7860

Thomas Kirchner (T)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.

Florencia Cidre-Aranaz (F)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
ORCID: 0000-0002-0246-7179

Thomas G P Grünewald (TGP)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. t.gruenewald@kitz-heidelberg.de.
Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. t.gruenewald@kitz-heidelberg.de.
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany. t.gruenewald@kitz-heidelberg.de.
Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. t.gruenewald@kitz-heidelberg.de.
ORCID: 0000-0003-0920-7377

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Estimation de Kaplan-Meier › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines de fusion oncogènes › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Thérapeutique › Biothérapie › Thérapie par l'interférence par ARN › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Ostéosarcome › Sarcome d'Ewing › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Therapeutic targeting of the PLK1-PRC1-axis...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Therapeutic targeting of the PLK1-PRC1-axis...