Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 09 2021
16 09 2021
Historique:
received:
18
06
2021
accepted:
25
08
2021
entrez:
17
9
2021
pubmed:
18
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Radioactive iodine (RAI) is safe and effective in most patients with hyperthyroidism but not all individuals are cured by the first dose, and most develop post-RAI hypothyroidism. Postoperative RAI therapy for remnant ablation is successful in 80-90% of thyroid cancer patients and sometimes induces remission of nonresectable cervical and/or distant metastatic disease but the effective tumor dose is usually not precisely known and must be moderated to avoid short- and long-term adverse effects on other tissues. The Collar Therapy Indicator (COTI) is a radiation detection device embedded in a cloth collar secured around the patient's neck and connected to a recording and data transmission box. In previously published experience, the data can be collected at multiple time points, reflecting local cervical RAI exposure and correlating well with conventional methods. We evaluated the real-time uptake of RAI in patients with hyperthyroid Graves' disease and thyroid cancer. We performed a pilot feasibility prospective study. Data were analyzed using R
Identifiants
pubmed: 34531443
doi: 10.1038/s41598-021-97408-y
pii: 10.1038/s41598-021-97408-y
pmc: PMC8446004
doi:
Substances chimiques
Iodine Radioisotopes
0
Banques de données
ClinicalTrials.gov
['NCT03517579']
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
18479Informations de copyright
© 2021. The Author(s).
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