Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia.
Claudin-5
autophagy
blood-brain barrier
hypoxia
permeability
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
07
2021
accepted:
03
08
2021
entrez:
17
9
2021
pubmed:
18
9
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Hypoxic injury to cerebrovascular endothelial cells (ECs) after stroke leads to blood-brain barrier (BBB) dysfunction, which is commonly associated with disruptions of endothelial tight junctions (TJs) and increased permeability. Therefore, maintaining the structural integrity and proper function of the BBB is essential for the homeostasis and physiological function of the central nervous system (CNS). Our previous study revealed that autophagy functions on protecting the BBB by regulating the dynamics of Claudin-5, the essential TJ protein, under short-term starvation or hypoxia conditions. Here, we show that in zebrafish and
Identifiants
pubmed: 34531766
doi: 10.3389/fphys.2021.737474
pmc: PMC8438321
doi:
Types de publication
Journal Article
Langues
eng
Pagination
737474Informations de copyright
Copyright © 2021 Yu, Li, Zhong, Li, Chen and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Transl Med. 2009 Nov 17;7:97
pubmed: 19919699
Front Physiol. 2019 Jan 18;10:2
pubmed: 30713499
Cell Mol Neurobiol. 2020 Nov 21;:
pubmed: 33222099
J Cell Sci. 2021 Jan 11;134(1):
pubmed: 33323504
Mol Neurobiol. 2016 Nov;53(9):5935-5947
pubmed: 26515186
Antioxid Redox Signal. 2014 Jan 1;20(1):146-63
pubmed: 23418728
Cell Tissue Res. 2006 Jul;325(1):3-11
pubmed: 16534602
Stroke. 2018 Jun;49(6):1571-1579
pubmed: 29724893
Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183298
pubmed: 32353377
Endocrinology. 2006 Dec;147(12):5600-10
pubmed: 16935840
Cell Death Dis. 2018 Jun 7;9(6):683
pubmed: 29880899
Nat Commun. 2019 Dec 20;10(1):5816
pubmed: 31862977
Expert Opin Ther Targets. 2017 Mar;21(3):305-317
pubmed: 28081644
Autophagy. 2020 Dec 7;:1-20
pubmed: 33280500
Prog Neurobiol. 2018 Apr - May;163-164:98-117
pubmed: 29331396
J Biol Chem. 2002 Mar 22;277(12):10201-8
pubmed: 11782481
J Pain Res. 2019 Aug 08;12:2473-2485
pubmed: 31496789
Free Radic Biol Med. 2011 Dec 1;51(11):1952-65
pubmed: 21958548
Cell Death Dis. 2019 Mar 8;10(3):234
pubmed: 30850584
Tissue Barriers. 2016 Jan 28;4(1):e1143544
pubmed: 27141424
Fluids Barriers CNS. 2019 Jan 29;16(1):3
pubmed: 30691500
Br J Anaesth. 2011 Jul;107(1):57-64
pubmed: 21596843
Genes Dev. 2010 Mar 1;24(5):491-501
pubmed: 20194441
Physiol Rev. 2019 Jan 1;99(1):21-78
pubmed: 30280653
Clin Sci (Lond). 2020 Nov 13;134(21):2835-2850
pubmed: 33146370
Front Physiol. 2020 Aug 06;11:914
pubmed: 32848858
Curr Neuropharmacol. 2021;19(5):629-640
pubmed: 32727333
Am J Physiol Cell Physiol. 2019 Feb 1;316(2):C135-C153
pubmed: 30379577
Prog Neurobiol. 2018 Feb;161:79-96
pubmed: 29217457
J Neurosci. 2012 Feb 29;32(9):3044-57
pubmed: 22378877
Fluids Barriers CNS. 2020 Nov 18;17(1):69
pubmed: 33208141
J Cell Biol. 2003 May 12;161(3):653-60
pubmed: 12743111
Metallomics. 2019 Aug 1;11(8):1372-1386
pubmed: 31267119
Biochem Biophys Res Commun. 1990 Dec 14;173(2):660-5
pubmed: 2175602
Front Physiol. 2016 Jun 02;7:206
pubmed: 27313545
Oxid Med Cell Longev. 2015;2015:489647
pubmed: 26000071
Nat Rev Immunol. 2009 Sep;9(9):609-17
pubmed: 19704417